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Loxapac: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Loxapac - General Information

An antipsychotic agent used in schizophrenia. [PubChem]

 

Pharmacology of Loxapac

Loxapac, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapac is a tranquilizer for which the exact mode of action has not been established.

 

Loxapac for patients

Patient Information:

Given the likelihood that some patients exposed chronically to neuroleptics
will develop tardive dyskinesia, it is advised that all patients in whom
chronic use is contemplated be given, if possible, full information about
this risk. The decision to inform patients and/or their guardians must
obviously take into account the clinical circumstances and the competency
of the patient to understand the information provided.

 

Loxapac Interactions

There have been rare reports of significant respiratory depression, stupor and/or hypotension with the concomitant use of loxapine and lorazepam.

The risk of using loxapine in combination with CNS-Active drugs has not been systematically evaluated. Therefore, caution is advised if the concomitant administration of loxapine and CNS-Active drugs is required.

 

Loxapac Contraindications

LOXITANE is contraindicated in comatose or severe drug-induced depressed states (alcohol, barbiturates, narcotics, etc.).

LOXITANE is contraindicated in individuals with known hypersensitivity to dibenzoxazepines.

 

Additional information about Loxapac

Loxapac Indication: For the management of the manifestations of psychotic disorders Mechanism Of Action: Loxapac is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapac has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior. Drug Interactions: Donepezil Possible antagonism of actionGalantamine Possible antagonism of actionRivastigmine Possible antagonism of action Food Interactions: Take with food to reduce irritation. Avoid alcohol. Generic Name: Loxapine Synonyms: Not Available Drug Category: Antipsychotics; Dopamine Antagonists Drug Type: Small Molecule; Approved Other Brand Names containing Loxapine: Cloxazepine; Dibenzacepin; Dibenzoazepine; Hydrofluoride 3170; Lossapina [Dcit]; Loxapac; Loxapin; Loxapina [Inn-Spanish]; Loxapine [Usan-Ban-Inn]; Loxapinum [Inn-Latin]; Loxepine; Loxitane C; Loxitane Im; Oxilapine; Absorption: Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers Toxicity (Overdose): LD50=65 mg/kg (Orally in mice) Protein Binding: Not Available Biotransformation: Hepatic Half Life: Oral-4 hours Dosage Forms of Loxapac: Tablet OralSolution OralLiquid Intramuscular Chemical IUPAC Name: 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,5]benzoxazepine Chemical Formula: C18H18ClN3O Loxapine on Wikipedia: https://en.wikipedia.org/wiki/Loxapine Organisms Affected: Humans and other mammals