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Lotusate: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Lotusate - General Information

Lotusate, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate duration of action. Lotusate is a schedule III drug in the U.S.

 

Pharmacology of Lotusate

Lotusate is a short to intermediate-acting barbiturate. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.

 

Additional information about Lotusate

Lotusate Indication: For use as a sedative and hypnotic. Mechanism Of Action: Lotusate binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Talbutal Synonyms: 5-Allyl-5-sec-butylbarbituric acid; sec-Butyl allyl barbituric acid Drug Category: Analgesics Drug Type: Small Molecule; Illicit; Approved Other Brand Names containing Talbutal: Latusate; Lotusate; Profundol; Absorption: Not Available Toxicity (Overdose): Symptoms of acute barbiturate poisoning include drowsiness, confusion, coma, respiratory depression, hypotension, and shock. Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Lotusate: Not Available Chemical IUPAC Name: 5-butan-2-yl-1,3-dimethyl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione Chemical Formula: C13H20N2O3 Talbutal on Wikipedia: https://en.wikipedia.org/wiki/Talbutal Organisms Affected: Humans and other mammals