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Lopac-D-122: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Lopac-D-122 - General Information

A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. [PubChem]

 

Pharmacology of Lopac-D-122

Lopac-D-122 is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

 

Lopac-D-122 for patients

 

Lopac-D-122 Interactions

 

Lopac-D-122 Contraindications

Domperidone should not be used when patient have gastrointestinal hemorrhage, mechanical obstruction or perforation problems. Domperidone accumulation has been reported in patients with hepatic impairment.

 

Additional information about Lopac-D-122

Lopac-D-122 Indication: For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting. Mechanism Of Action: Gastrointestinal emptying (delayed) adjunct; peristaltic stimulant: The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Lopac-D-122 facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. Drug Interactions: Not Available Food Interactions: Take 15 to 30 minutes before meals. Generic Name: Domperidone Synonyms: Not Available Drug Category: Antiemetics; Dopamine Antagonists Drug Type: Small Molecule; Approved Other Brand Names containing Domperidone: Motilium; Nauzelin; Lopac-D-122; Absorption: Fast Toxicity (Overdose): Side effects include galactorrhea, gynecomastia, or menstrual irregularities. Protein Binding: 91%-93% Biotransformation: Not Available Half Life: 7 hours Dosage Forms of Lopac-D-122: Tablet Oral Chemical IUPAC Name: 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one Chemical Formula: C22H24ClN5O2 Domperidone on Wikipedia: https://en.wikipedia.org/wiki/Domperidone Organisms Affected: Humans and other mammals