Lidanil
Lidanil - General Information
A phenothiazine antipsychotic with effects similar to chlorpromazine. [PubChem]
Pharmacology of Lidanil
Lidanil, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer. Pharmacological studies in laboratory animals have established that mesoridazine has a spectrum of pharmacodynamic actions typical of a major tranquilizer. In common with other tranquilizers it inhibits spontaneous motor activity in mice, prolongs thiopental and hexobarbital sleeping time in mice and produces spindles and block of arousal reaction in the EEG of rabbits. It is effective in blocking spinal reflexes in the cut and antagonizes d-amphetamine excitation and toxicity in grouped mice. It shows a moderate adrenergic blocking activity in vitro and in vivo and antagonizes 5-hydroxytryptamine in vivo. Intravenously administered, it lowers the blood pressure of anesthetized dogs. It has a weak antiacetylcholine effect in vitro.
Lidanil for patients
Given the likelihood that some patients exposed chronically to neuroleptics will develop tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full information about this risk.
Lidanil Interactions
No information provided.
Lidanil Contraindications
As with other phenothiazines, Serentil (mesoridazine besylate) is contraindicated in severe central nervous system depression or comatose states from any cause including drug induced central nervous system depression.
Serentil (mesoridazine besylate) is contraindicated in individuals who have previously shown hypersensitivity to the drug.
Additional information about Lidanil
Lidanil Indication: Used in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses.
Mechanism Of Action: Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. In addition, the phenothiazines exhibit at least part of their activities through depression of hypothalamic centers. Neurochemically, the phenothiazines are thought to exert their effects by a central adrenergic blocking action.
Drug Interactions: Amiodarone Increased risk of cardiotoxicity and arrhythmias
Amitriptyline Increased risk of cardiotoxicity and arrhythmias
Astemizole Increased risk of cardiotoxicity and arrhythmias
Bretylium Increased risk of cardiotoxicity and arrhythmias
Chloroquine Increased risk of cardiotoxicity and arrhythmias
Chlorpromazine Increased risk of cardiotoxicity and arrhythmias
Cisapride Increased risk of cardiotoxicity and arrhythmias
Diltiazem Increased risk of cardiotoxicity and arrhythmias
Diphenhydramine Increased risk of cardiotoxicity and arrhythmias
Disopyramide Increased risk of cardiotoxicity and arrhythmias
Dofetilide Increased risk of cardiotoxicity and arrhythmias
Doxepin Increased risk of cardiotoxicity and arrhythmias
Erythromycin Increased risk of cardiotoxicity and arrhythmias
Flecainide Increased risk of cardiotoxicity and arrhythmias
Fluoxetine Increased risk of cardiotoxicity and arrhythmias
Fluvoxamine Increased risk of cardiotoxicity and arrhythmias
Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Halofantrine Increased risk of cardiotoxicity and arrhythmias
Haloperidol Increased risk of cardiotoxicity and arrhythmias
Imipramine Increased risk of cardiotoxicity and arrhythmias
Josamycin Increased risk of cardiotoxicity and arrhythmias
Levofloxacin Increased risk of cardiotoxicity and arrhythmias
Maprotiline Increased risk of cardiotoxicity and arrhythmias
Metrizamide Increased risk of cardiotoxicity and arrhythmias
Paroxetine Increased risk of cardiotoxicity and arrhythmias
Penicillin G Increased risk of cardiotoxicity and arrhythmias
Pentamidine Increased risk of cardiotoxicity and arrhythmias
Pimozide Increased risk of cardiotoxicity and arrhythmias
Pindolol Increased risk of cardiotoxicity and arrhythmias
Procainamide Increased risk of cardiotoxicity and arrhythmias
Propafenone Increased risk of cardiotoxicity and arrhythmias
Propranolol Increased risk of cardiotoxicity and arrhythmias
Quinidine Increased risk of cardiotoxicity and arrhythmias
Quinidine barbiturate Increased risk of cardiotoxicity and arrhythmias
Quinine Increased risk of cardiotoxicity and arrhythmias
Sotalol Increased risk of cardiotoxicity and arrhythmias
Sertindole Increased risk of cardiotoxicity and arrhythmias
Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Ziprasidone Increased risk of cardiotoxicity and arrhythmias
Spiramycin Increased risk of cardiotoxicity and arrhythmias
Rivastigmine Possible antagonism of action
Bromocriptine The phenothiazine decreases the effect of bromocriptine
Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Guanethidine The agent decreases the effect of guanethidine
Amphetamine Decreased anorexic effect, may increase psychotic symptoms
Benzphetamine Decreased anorexic effect, may increase psychotic symptoms
Dexfenfluramine Decreased anorexic effect, may increase psychotic symptoms
Diethylpropion Decreased anorexic effect, may increase psychotic symptoms
Dextroamphetamine Decreased anorexic effect, may increase psychotic symptoms
Fenfluramine Decreased anorexic effect, may increase psychotic symptoms
Mazindol Decreased anorexic effect, may increase psychotic symptoms
Methamphetamine Decreased anorexic effect, may increase psychotic symptoms
Phenylpropanolamine Decreased anorexic effect, may increase psychotic symptoms
Phentermine Decreased anorexic effect, may increase psychotic symptoms
Phenmetrazine Decreased anorexic effect, may increase psychotic symptoms
Phendimetrazine Decreased anorexic effect, may increase psychotic symptoms
Food Interactions: Not Available
Generic Name: Mesoridazine
Synonyms: Thioridazien Thiomethyl Sulfoxide; Thioridazine Monosulfoxide Analog; Thioridazine Thiomethyl Sulfoxide; TPS-23; TPS23
Drug Category: Antipsychotics; Phenothiazines
Drug Type: Small Molecule; Approved
Other Brand Names containing Mesoridazine: Calodal; Lidanar; Lidanil; Serentil; Serentil Concentrate;
Absorption: Well absorbed from the gastrointestinal tract.
Toxicity (Overdose): Oral LD50 is 560 ± 62.5 mg/kg and 644 ± 48 mg/kg in mouse and rat, respectively. Symptoms of overdose may include emesis, muscle tremors, decreased food intake and death associated with aspiration of oral-gastric contents into the respiratory system.
Protein Binding: 4%
Biotransformation: Not Available
Half Life: 24 to 48 hours
Dosage Forms of Lidanil: Tablet Oral
Injection, solution Intramuscular
Chemical IUPAC Name: 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfinylphenothiazine
Chemical Formula: C21H26N2OS2
Mesoridazine on Wikipedia: https://en.wikipedia.org/wiki/Mesoridazine
Organisms Affected: Humans and other mammals
