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Lidanil: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Lidanil - General Information

A phenothiazine antipsychotic with effects similar to chlorpromazine. [PubChem]

 

Pharmacology of Lidanil

Lidanil, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer. Pharmacological studies in laboratory animals have established that mesoridazine has a spectrum of pharmacodynamic actions typical of a major tranquilizer. In common with other tranquilizers it inhibits spontaneous motor activity in mice, prolongs thiopental and hexobarbital sleeping time in mice and produces spindles and block of arousal reaction in the EEG of rabbits. It is effective in blocking spinal reflexes in the cut and antagonizes d-amphetamine excitation and toxicity in grouped mice. It shows a moderate adrenergic blocking activity in vitro and in vivo and antagonizes 5-hydroxytryptamine in vivo. Intravenously administered, it lowers the blood pressure of anesthetized dogs. It has a weak antiacetylcholine effect in vitro.

 

Lidanil for patients

Given the likelihood that some patients exposed chronically to neuroleptics will develop tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full information about this risk.

 

Lidanil Interactions

No information provided.

 

Lidanil Contraindications

As with other phenothiazines, Serentil (mesoridazine besylate) is contraindicated in severe central nervous system depression or comatose states from any cause including drug induced central nervous system depression.

Serentil (mesoridazine besylate) is contraindicated in individuals who have previously shown hypersensitivity to the drug.

 

Additional information about Lidanil

Lidanil Indication: Used in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses. Mechanism Of Action: Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. In addition, the phenothiazines exhibit at least part of their activities through depression of hypothalamic centers. Neurochemically, the phenothiazines are thought to exert their effects by a central adrenergic blocking action. Drug Interactions: Amiodarone Increased risk of cardiotoxicity and arrhythmiasAmitriptyline Increased risk of cardiotoxicity and arrhythmiasAstemizole Increased risk of cardiotoxicity and arrhythmiasBretylium Increased risk of cardiotoxicity and arrhythmiasChloroquine Increased risk of cardiotoxicity and arrhythmiasChlorpromazine Increased risk of cardiotoxicity and arrhythmiasCisapride Increased risk of cardiotoxicity and arrhythmiasDiltiazem Increased risk of cardiotoxicity and arrhythmiasDiphenhydramine Increased risk of cardiotoxicity and arrhythmiasDisopyramide Increased risk of cardiotoxicity and arrhythmiasDofetilide Increased risk of cardiotoxicity and arrhythmiasDoxepin Increased risk of cardiotoxicity and arrhythmiasErythromycin Increased risk of cardiotoxicity and arrhythmiasFlecainide Increased risk of cardiotoxicity and arrhythmiasFluoxetine Increased risk of cardiotoxicity and arrhythmiasFluvoxamine Increased risk of cardiotoxicity and arrhythmiasGatifloxacin Increased risk of cardiotoxicity and arrhythmiasGrepafloxacin Increased risk of cardiotoxicity and arrhythmiasHalofantrine Increased risk of cardiotoxicity and arrhythmiasHaloperidol Increased risk of cardiotoxicity and arrhythmiasImipramine Increased risk of cardiotoxicity and arrhythmiasJosamycin Increased risk of cardiotoxicity and arrhythmiasLevofloxacin Increased risk of cardiotoxicity and arrhythmiasMaprotiline Increased risk of cardiotoxicity and arrhythmiasMetrizamide Increased risk of cardiotoxicity and arrhythmiasParoxetine Increased risk of cardiotoxicity and arrhythmiasPenicillin G Increased risk of cardiotoxicity and arrhythmiasPentamidine Increased risk of cardiotoxicity and arrhythmiasPimozide Increased risk of cardiotoxicity and arrhythmiasPindolol Increased risk of cardiotoxicity and arrhythmiasProcainamide Increased risk of cardiotoxicity and arrhythmiasPropafenone Increased risk of cardiotoxicity and arrhythmiasPropranolol Increased risk of cardiotoxicity and arrhythmiasQuinidine Increased risk of cardiotoxicity and arrhythmiasQuinidine barbiturate Increased risk of cardiotoxicity and arrhythmiasQuinine Increased risk of cardiotoxicity and arrhythmiasSotalol Increased risk of cardiotoxicity and arrhythmiasSertindole Increased risk of cardiotoxicity and arrhythmiasSparfloxacin Increased risk of cardiotoxicity and arrhythmiasTerfenadine Increased risk of cardiotoxicity and arrhythmiasZiprasidone Increased risk of cardiotoxicity and arrhythmiasSpiramycin Increased risk of cardiotoxicity and arrhythmiasRivastigmine Possible antagonism of actionBromocriptine The phenothiazine decreases the effect of bromocriptineDonepezil Possible antagonism of actionGalantamine Possible antagonism of actionGuanethidine The agent decreases the effect of guanethidineAmphetamine Decreased anorexic effect, may increase psychotic symptomsBenzphetamine Decreased anorexic effect, may increase psychotic symptomsDexfenfluramine Decreased anorexic effect, may increase psychotic symptomsDiethylpropion Decreased anorexic effect, may increase psychotic symptomsDextroamphetamine Decreased anorexic effect, may increase psychotic symptomsFenfluramine Decreased anorexic effect, may increase psychotic symptomsMazindol Decreased anorexic effect, may increase psychotic symptomsMethamphetamine Decreased anorexic effect, may increase psychotic symptomsPhenylpropanolamine Decreased anorexic effect, may increase psychotic symptomsPhentermine Decreased anorexic effect, may increase psychotic symptomsPhenmetrazine Decreased anorexic effect, may increase psychotic symptomsPhendimetrazine Decreased anorexic effect, may increase psychotic symptoms Food Interactions: Not Available Generic Name: Mesoridazine Synonyms: Thioridazien Thiomethyl Sulfoxide; Thioridazine Monosulfoxide Analog; Thioridazine Thiomethyl Sulfoxide; TPS-23; TPS23 Drug Category: Antipsychotics; Phenothiazines Drug Type: Small Molecule; Approved Other Brand Names containing Mesoridazine: Calodal; Lidanar; Lidanil; Serentil; Serentil Concentrate; Absorption: Well absorbed from the gastrointestinal tract. Toxicity (Overdose): Oral LD50 is 560 ± 62.5 mg/kg and 644 ± 48 mg/kg in mouse and rat, respectively. Symptoms of overdose may include emesis, muscle tremors, decreased food intake and death associated with aspiration of oral-gastric contents into the respiratory system. Protein Binding: 4% Biotransformation: Not Available Half Life: 24 to 48 hours Dosage Forms of Lidanil: Tablet OralInjection, solution Intramuscular Chemical IUPAC Name: 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfinylphenothiazine Chemical Formula: C21H26N2OS2 Mesoridazine on Wikipedia: https://en.wikipedia.org/wiki/Mesoridazine Organisms Affected: Humans and other mammals