Medical Information Only: This medication is not sold on this site. The information provided is for reference purposes only. Please consult your local physician or pharmacist for treatment.

Inversine: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Inversine - General Information

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Inversine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool. [PubChem]

 

Pharmacology of Inversine

Inversine is a potent, oral antihypertensive agent and ganglion blocker, and is a secondary amine. Inversine is indicated for the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension. Inversine reduces blood pressure in both normotensive and hypertensive individuals. A small oral dosage often produces a smooth and predictable reduction of blood pressure. Although this antihypertensive effect is predominantly orthostatic, the supine blood pressure is also significantly reduced. Inversine crosses the blood-brain and placental barriers.

 

Inversine for patients

 

Inversine Interactions

Patients receiving antibiotics and sulfonamides generally should not be treated with ganglion blockers.

The action of Mecamylamine may be potentiated by anesthesia, other antihypertensive drugs and alcohol.

 

Inversine Contraindications

Mecamylamine should not be used in mild, moderate, labile hypertension and may prove unsuitable in uncooperative patients. It is contraindicated in coronary insufficiency or recent myocardial infarction. Mecamylamine should be given with great discretion, if at all, when renal insufficiency is manifested by a rising or elevated BUN. The drug is contraindicated in uremia. Patients receiving antibiotics and sulfonamides should generally not be treated with ganglion blockers. Other contraindications are glaucoma, organic pyloric stenosis or hypersensitivity to the product.

 

Additional information about Inversine

Inversine Indication: For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension Mechanism Of Action: Inversine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Inversine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Mecamylamine Synonyms: 2-Methylamino-2,3,3-trimethylnorbornane; 2-Methylaminoisocamphane; 3-Methylaminoisocamphane; 3-Methylaminoisocamphane hydrochloride; Mecamylamine Hydrochloride; Mecamilamina Drug Category: Antihypertensive Agents Drug Type: Small Molecule; Approved Other Brand Names containing Mecamylamine: Inversine; Inversine hydrochloride; Mecamine; Mecamine hydrochloride; Mekamin hydrochloride; Mekamine; Mevasin hydrochloride; Mevasine; Revertina; Versamine; Absorption: Mecamylamine is almost completely absorbed from the gastrointestinal tract Toxicity (Overdose): Not Available Protein Binding: 40% Biotransformation: Not Available Half Life: Not Available Dosage Forms of Inversine: Tablet Oral Chemical IUPAC Name: N,5,6,6-tetramethylbicyclo[2.2.1]heptan-5-amine Chemical Formula: C11H21N Mecamylamine on Wikipedia: https://en.wikipedia.org/wiki/Mecamylamine Organisms Affected: Humans and other mammals