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Iminourea: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Iminourea - General Information

A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC. [PubChem]

 

Pharmacology of Iminourea

Iminourea apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.

 

Iminourea for patients

 

Iminourea Interactions

 

Iminourea Contraindications

Guanidine is contraindicated in individuals with a history of intolerance or allergy to this drug.

 

Additional information about Iminourea

Iminourea Indication: For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis. Mechanism Of Action: Not Available Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Guanidine Synonyms: Not Available Drug Category: Parasympathomimetics Drug Type: Small Molecule; Approved Other Brand Names containing Guanidine: Aminomethanamidine; Carbamamidine; Carbamidine; Guanidin; Guanidine Hydrochloride; Guanidinium Chloride; Guanidinium Sulfate; Imidourea; Iminourea; Absorption: Rapidly absorbed and distributed Toxicity (Overdose): LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances. Protein Binding: Not Available Biotransformation: Not metabolized. Half Life: 7-8 hours Dosage Forms of Iminourea: Not Available Chemical IUPAC Name: guanidine Chemical Formula: CH5N3 Guanidine on Wikipedia: https://en.wikipedia.org/wiki/Guanidine Organisms Affected: Humans and other mammals