IFEX: Full Drug Profile

IFEX - General Information

Positional isomer of cyclophosphamide which is active as an alkylating agent and an immunosuppressive agent. [PubChem]

Pharmacology of IFEX

IFEX selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

IFEX for patients

IFEX Interactions

The physician should be alert for possible combined drug actions, desirable or undesirable, involving ifosfamide even though ifosfamide has been used successfully concurrently with other drugs, including other cytotoxic drugs.

IFEX Contraindications

Continued use of IFEX is contraindicated in patients with severely depressed bone marrow function. IFEX is also contraindicated in patients who have demonstrated a previous hypersensitivity to it.

Additional information about IFEX

IFEX Indication

For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

Mechanism Of Action

After metabolic activation, active metabolites of ifosfamide alkylate or bind with many intracellular molecular structures, including nucleic acids. The cytotoxic action is primarily due to cross-linking of strands of DNA and RNA, as well as inhibition of protein synthesis.

Generic Name

Ifosfamide

Synonyms

Asta Z 4942; Ifosfamid; Ifosfamide Sterile; Ifsofamide; Iphosphamid; Iphosphamide; Isophosphamide; Isofosfamide; I-Phosphamide

Drug Category

Antineoplastic Agents; Immunosuppressive Agents

Drug Type

Small Molecule; Approved

Other Brand Names containing Ifosfamide

Cyfos; Holoxan 1000; IFEX; Ifex/Mesnex Kit; Ifosfamide/Mesna Kit; Isoendoxan; Mitoxana; Naxamide;

Toxicity (Overdose)

LD₅₀ (mouse) = 390-1005 mg/kg, LD₅₀ (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

Protein Binding

Minimal

Biotransformation

Primarily hepatic

Half Life

7-15 hours

Dosage Forms of IFEX

Powder, for solution Intravenous

Chemical IUPAC Name

N,3-bis(2-chloroethyl)-2-oxo-1-oxa-3-aza-2$l^{5}-phosphacyclohexan-2-amine

Chemical Formula

C7H15Cl2N2O2P

Ifosfamide on Wikipedia

https://en.wikipedia.org/wiki/Ifosfamide

Organisms Affected

Humans and other mammals