Humatin

Humatin - General Information

An oligosaccharide antibiotic produced by various streptomyces. [PubChem]

Pharmacology of Humatin

Humatin is a broad spectrum antibiotic produced by Streptomyces rimosus var. paromomycinus. The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin.

Humatin for patients

Humatin Interactions

Humatin Contraindications

Paromomycin sulfate is contraindicated in individuals with a history of previous hypersensitivity reactions to it. It is also contraindicated in intestinal obstruction.

Additional information about Humatin

Humatin Indication: For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy.
Mechanism Of Action: Humatin inhibits protein synthesis by binding to 16S ribosomal RNA.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Paromomycin
Synonyms: Aminosidin; Aminosidine; Paramomycin sulfate
Drug Category: Antibacterial Agents
Drug Type: Small Molecule; Approved; Investigational

Other Brand Names containing Paromomycin: Humatin;
Absorption: Poorly absorbed after oral administration, with almost 100% of the drug recoverable in the stool.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Humatin: Capsule Oral
Capsule Oral
Chemical IUPAC Name: (2R,3S,4R,5R,6S)-5-amino-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol
Chemical Formula: C23H45N5O14
Paromomycin on Wikipedia: https://en.wikipedia.org/wiki/Paromomycin_sulfate
Organisms Affected: Enteric bacteria and other eubacteria