Gastrix: Full Drug Profile

Gastrix - General Information

Gastrix is an anticholinergic drug (trade name Daricon) used in treating peptic ulcers.

Pharmacology of Gastrix

Gastrix is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Gastrix is an antimuscarinic, anticholinergic drug.

Additional information about Gastrix

Gastrix Indication

For the treatment of peptic ulcer disease and the relief of smooth muscle spasms in gastrointestinal disorders.

Mechanism Of Action

Gastrix binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Oxphencyclimine inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.

Generic Name

Oxyphencyclimine

Synonyms

Oxifencicliminum [Inn-Spanish]; Oxiphencycliminum; Oxyphencyclimine Hydrochloride; Oxyphencycliminum [Inn-Latin]

Drug Category

Anticholinergic Agents; Antispasmodics

Drug Type

Small Molecule; Approved

Other Brand Names containing Oxyphencyclimine

Antulcus; Caridan; Cycmin; Daricol; Daricon; Dominil; Enterex; Gastrix; Manir; Naridan; Oximin; Setrol; Spazamin; Syklifen; Ulcociclinina; Vio-Thene; W-T Anticholinergic; Zamanil;

Chemical IUPAC Name

(1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

Chemical Formula

C20H28N2O3

Organisms Affected

Humans and other mammals