Gabren: Full Drug Profile
Gabren - General Information
Gabren is an analog and prodrug of gamma-aminobutyric acid. It is commonly used in the treatment of epilepsy. It has agonistic activity for both the GABAA and GABAB receptors. Gabren has been investigated for many diseases besides epilepsy, including Parkinson's disease, schizophrenia, clinical depression and anxiety disorder with varying success.
Pharmacology of Gabren
Gabren, a fatty acid derivative, is a GABA receptor agonist used to treat the symptoms of epilepsy.
Additional information about Gabren
Gabren Indication: Indicated for the treatment of epilepsy. Mechanism Of Action: Gabren binds to both GABAA and GABAB receptors located on the terminals of primary afferent fibers. Binding to GABAA results in an increased affinity of the GABA receptor for the amino acid, an augmented flux of chloride ions across the terminal membrane, and an increase in the amount of presynaptic inhibition. Activation of the GABAB receptors retards the influx of calcium ions into the terminals, thereby reducing the evoked release of excitatory amino acids and possibly other transmitters. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Progabide Synonyms: Progabidum [Inn-Latin]; Progabide [Usan-Ban-Inn]; Progabida [Inn-Spanish]; Halogabide Drug Category: Antiparkinson Agents; Antidyskinetics; Antidepressants; Anticonvulsants Drug Type: Small Molecule; Approved Other Brand Names containing Progabide: Gabren; Gabrene; Absorption: Well absorbed with a bioavailability of 60% Toxicity (Overdose): Not Available Protein Binding: 95% Biotransformation: Hepatic Half Life: 4 hours Dosage Forms of Gabren: Not Available Chemical IUPAC Name: 4-[[(E)-(4-chlorophenyl)-(3-fluoro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]butanamide Chemical Formula: C17H16ClFN2O2 Progabide on Wikipedia: https://en.wikipedia.org/wiki/Progabide Organisms Affected: Humans and other mammals