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Fusidine: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Fusidine - General Information

An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.

 

Pharmacology of Fusidine

Fusidic acid is a bacteriostatic antibiotic that is often used topically in creams and eyedrops, but may also be given systemically as tablets or injections.

 

Additional information about Fusidine

Fusidine Indication: For the treatment of bacterial infections. Mechanism Of Action: Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. Drug Interactions: Amprenavir The protease inhibitor increases the effect and toxicity of fusidic acidFosamprenavir The protease inhibitor increases the effect and toxicity of fusidic acidNelfinavir The protease inhibitor increases the effect and toxicity of fusidic acidRitonavir The protease inhibitor increases the effect and toxicity of fusidic acidSaquinavir The protease inhibitor increases the effect and toxicity of fusidic acidAtorvastatin Increased risk of myopathy/rhabdomyolysisSimvastatin Increased risk of myopathy/rhabdomyolysisIndinavir Indinavir increases the effect and toxicity of fusidic acid Food Interactions: Take with food to reduce irritation. Generic Name: Fusidic Acid Synonyms: Diethanolamine fusidate; Fucidic acid; Fusidate; Fusidate Sodium; Fucidate Sodium; Fucidate Drug Category: Antibacterial Agents Drug Type: Small Molecule; Approved Other Brand Names containing Fusidic Acid: Fucidin Cream 2%; Fucithalmic; Fusidine; Ramycin; Fucidin; Fucidin acid; Fucidine; Absorption: Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose. Toxicity (Overdose): Not Available Protein Binding: 97 to 99% Biotransformation: Metabolites include dicarboxylic ester/acid, 3-keto fusidic acid, hydroxy fusidic acid, glucuronide fusidic acid and a glycol metabolite. Half Life: Approximately 5 to 6 hours in adults. Dosage Forms of Fusidine: Not Available Chemical IUPAC Name: (2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid Chemical Formula: C31H48O6 Fusidic Acid on Wikipedia: https://en.wikipedia.org/wiki/Fusidic_acid Organisms Affected: Enteric bacteria and other eubacteria