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Fludura: Full Drug Profile

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

Fludura - General Information

Fludura (marketed as fludarabine phosphate under the trade name Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. [Wikipedia]

 

Pharmacology of Fludura

Fludura is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells.

 

Fludura for patients

FLUDARA FOR INJECTION is a potent antineoplastic agent with potentially significant toxic side effects. Patients undergoing therapy should be closely observed for signs of hematologic and nonhematologic toxicity. Periodic assessment of peripheral blood counts is recommended to detect the development of anemia, neutropenia and thrombocytopenia.

 

Fludura Interactions

The use of FLUDARA FOR INJECTION in combination with pentostatin is not recommended due to the risk of severe pulmonary toxicity.

 

Fludura Contraindications

FLUDARA FOR INJECTION is contraindicated in those patients who are hypersensitive to this drug or its components.

 

Additional information about Fludura

Fludura Indication: For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen Mechanism Of Action: Fludura phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted. Drug Interactions: Dipyridamole Dipyridamole decreases the effect of fludarabinePentostatin Unacceptable pulmonary toxicity Food Interactions: Take without regard to meals.Food slightly increases product bioavailability. Generic Name: Fludarabine Synonyms: FAMP; Fludarabine 5'-monophosphate; Fludarabine monophosphate; Fludarabine phosphate Drug Category: Immunosuppressive Agents; Antimetabolites; Antineoplastic Agents Drug Type: Small Molecule; Approved Other Brand Names containing Fludarabine: Fludara; Fludura; Absorption: Bioavailability is 55% following oral administration. Toxicity (Overdose): Not Available Protein Binding: 19-29% Biotransformation: Not Available Half Life: 20 hours Dosage Forms of Fludura: Tablet OralPowder, for solution Intravenous Chemical IUPAC Name: [(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate Chemical Formula: C10H13FN5O7P Fludarabine on Wikipedia: https://en.wikipedia.org/wiki/Fludarabine Organisms Affected: Humans and other mammals