Dosing and uses of KPhos Original, NeutraPhos (potassium acid phosphate)
Adult dosage forms and strengths
tablet
- 500mg
Elevated Urinary pH
1-2 tabs (500-1000mg) dissolved in 6-8 oz of water; take PO four times daily with meals and at bedtime
Pediatric dosage forms and strengths
Safety and efficacy not established
KPhos Original, NeutraPhos (potassium acid phosphate) adverse (side) effects
Frequency not defined
Diarrhea
Nausea/vomiting
Stomach pain
Flatulence
Bradycardia
Hyperkalemia
Local tissue necrosis with extravasation
Weakness
Dyspnea
Hypocalcemia
Tetany
Phosphate intoxication
Hypotension
Arrhythmia
Warnings
Contraindications
Hyperphosphatemia, severe renal impairment, hyperkalemia, infected phophate stones
Cautions
May cause hyperkalemia; use caution in patients who require regulation of serum potassium concentrations
Patients may experience mild laxative effects within first few days of therapy
Use caution in patients with severe adrenal insufficiency, cardiac disease, myotonia congenita, pancreatitis, parathyroid disease, renal calculi, renal impairment, tissue breakdowns (burns), or rickets
Pregnancy and lactation
Pregnancy category: C
Lactation: Use with caution
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of KPhos Original, NeutraPhos (potassium acid phosphate)
Mechanism of action
Intracellular cation essential in physiological processes including transmission of nerve impulses, glucose utilization, muscle contractions, and enzyme activity
Acidifies urine
Pharmacokinetics
Distribution: Enters cells from extracellular fluid via active transport
Absorption: Well absorbed from upper GI tract
Excretion: Urine (primarily); skin and feces (small amount)
