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potassium chloride (KDur, Slow K, Kaon Cl 10, KCl, K10, Klor-Con M, Klor Con M10, Klor Con M15, Klor Con M20, KlorCon, Klotrix, KTab, MicroK, K8)

 

Classes: Electrolyte Supplements, Parenteral; Electrolytes

Dosing and uses of Stelara (ustekinumab)

 

Adult dosage forms and strengths

tablet

  • 20mEq

tablet, extended-release

  • 8mEq
  • 10mEq
  • 15mEq
  • 20mEq

capsules, extended-release

  • 8mEq
  • 10mEq

injectable solution

  • 1mEq/mL
  • 1.5mEq/mL
  • 2mEq/mL
  • 3mEq/mL
  • 4mEq/mL

premix IV in plastic container

  • 10mEq
  • 20mEq
  • 30mEq
  • 40mEq

 

Hypokalemia

20-40 mEq PO BID-QId

 

Hypokalemia Prophylaxis

Start: 20 mEq PO qDay

Dosing considerations

  • Dosing varies; adjust to serum potassium levels

 

Pediatric dosage forms and strengths

tablet

  • 20mEq

tablet, extended-release

  • 8mEq
  • 10mEq
  • 15mEq
  • 20mEq

capsules, extended-release

  • 8mEq
  • 10mEq

injectable solution

  • 1mEq/mL
  • 1.5mEq/mL
  • 2mEq/mL
  • 3mEq/mL
  • 4mEq/mL

premixed IV in plastic container

  • 10mEq
  • 20mEq
  • 30mEq
  • 40mEq

 

Hypokalemia

0.5-2 mEq/kg PO q12hr

Monitor closely: 0.5 mEq/kg/hr IV for 1-2 hr

 

Stelara (ustekinumab) adverse (side) effects

Frequency not defined

Arrhythmias

Bleeding

Diarrhea

Dyspepsia

Hyperkalemia

Nausea

Rash

Vomiting

 

Warnings

Contraindications

Hypersensitivity

Untreated Addison disease

Hyperkalemia

Renal failure

 

Cautions

CV disease

Impaired renal fxn

 

Pregnancy and lactation

Pregnancy category: C

Lactation: N/A

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Stelara (ustekinumab)

Mechanism of action

Essential in physiologic processes

 

Elimination

Excretion: Urine

 

Administration

IV Incompatibilities

Additive: Ampho B

Y-site: Diazepam

 

IV Compatibilities

Additive: Aminophylline, amiodarone, Ca gluconate, cimetidine, clindamycin, dobutamine, dopamine, erythromycin, furosemide, heparin, hydrocortisone, lidocaine, norepinephrine, Na bicarb, vancomycin, verapamiL

Y-site: Amiodarone, aminophylline, ampicillin, atropine, Ca gluconate, dobutamine, dopamine, epinephrine, esmolol, fentanyl, furosemide, heparin, lidocaine, morphine, norepinephrine, Na bicarB

Not spec.: Cefazolin, tetracycline