Gotu Kola (brahmabuti, centella asiatica, hydrocotyle, Indian pennywort, Indian water navelwort, madescassol, marsh penny, talepetrako, thick-leaved pennywort, white rot): Dosing and Uses

Suggested dosing of Brahmabuti, centella asiatica (gotu kola)

Extract

60mg PO BID-TId

Dried leaves

600 mg PO TId

Tea

1 cup PO TID; 600 mg dried leaves/150 ml water

Other Information

Topical: apply 1% cream daily

Suggested uses of Brahmabuti, centella asiatica (gotu kola)

Abdominal disorders, aphrodisiac, common cold/flu, fatigue, memory enhancer, varicose veins, venous insufficiency

Topical: hypertrophic scarring, psoriasis, wound healing

Efficacy

Possibly effective for listed uses

Brahmabuti, centella asiatica (gotu kola) adverse (side) effects

Frequency not defined

GI upset

Nausea

Photosensitivity

Pruritis

Topical: Allergic contact dermatitis

Burning

Large dose: Drowsiness

Hypercholesterolemia

Hyperglycemia

Hypertension

Hypertriglyceridemia

Sedation

Warnings

Contraindications

None reported

Cautions

Concurrent sedative agents, diabetes mellitus, hyperlipidemia

Pregnancy and lactation

Pregnancy category: avoid use

Lactation: avoid use

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Pharmacology of Brahmabuti, centella asiatica (gotu kola)

Metabolism: N/A

Excretion: N/A

Mechanism of action

Triterpene compounds stimulate connective tissue repair, keratinization

Asiaticoside derivatives protect neurons from beta-amyloid toxicity