Lovenox vs. Fragmin

• Are Fragmin and Lovenox the Same Thing?
• What Are Possible Side Effects of Lovenox?
• What Are Possible Side Effects of Fragmin?
• What Is Lovenox?
• What Is Fragmin?
• What Drugs Interact with Lovenox?
• What Drugs Interact with Fragmin?
• How Should Lovenox Be Taken?
• How Should Fragmin Be Taken?

Lovenox (enoxaparin sodium) Injection and Fragmin (dalteparin) are blood thinners (anticoagulants) used to prevent blood clots that are sometimes called deep vein thrombosis (DVT), which can lead to blood clots in the lungs. Lovenox and Fragmin are also used to prevent blood vessel complications in people with certain types of angina (chest pain) or heart attacks called non-Q-wave myocardial infarction or ST-segment elevation myocardial infarction.

Side effects of Lovenox and Fragmin that are similar include injection site reactions (swelling, pain, irritation, bruising, swelling, or redness).

Side effects of Lovenox that are different from Fragmin include nausea, diarrhea, fever, or swelling in your hands or feet.

Side effects of Fragmin that are different from Lovenox include easy bruising or bleeding.

Both Lovenox and Fragmin may interact with other blood thinners, aspirin and other salicylates, or nonsteroidal anti-inflammatory drugs (NSAIDs).

Lovenox may also interact with sulfinpyrazone.

Fragmin may also interact with dextran, abciximab, tirofiban, cilostazol, eltrombopag, oprelvekin, romiplostim, or lepirudin.

Common side effects of Lovenox include:

• nausea,
• diarrhea,
• fever,
• swelling in your hands or feet, or
• injection site reactions (swelling, pain, bruising, or redness).

Common side effects of Fragmin include:

• easy bruising or bleeding, or
• pain, redness, irritation, bruising, or swelling where the medicine was injected.
• Fragmin can cause bleeding if its effect on your blood clotting proteins is too strong.

Tell your doctor if you have serious side effects of Fragmin including:

• serious signs of bleeding, including unusual pain/swelling/discomfort,
• unusual or prolonged bleeding,
• unusual or easy bruising,
• purple or red pinpoints under your skin,
• dark urine,
• black or bloody stools,
• severe headache,
• confusion,
• trouble concentrating,
• vision changes,
• unusual dizziness,
• pale skin,
• shortness of breath,
• trouble breating,
• rapid heart rate,
• lightheartedness,
• fainting,
• coughing up blood or vomit that looks like coffee grounds,
• numbness, tingling, or muscle weakness (especially in your legs and feet),
• loss of movement in any part of your body,
• problems with speech, vision, or balance,
• seizures, or
• sudden weakness.

Lovenox (enoxaparin sodium) Injection is an anticoagulant (blood thinner) used to prevent blood clots that are sometimes called deep vein thrombosis (DVT), which can lead to blood clots in the lungs. A DVT can occur after certain types of surgery, or in people who are bed-ridden due to a prolonged illness. Lovenox is also used to prevent blood vessel complications in people with certain types of angina (chest pain) or heart attacks called non-Q-wave myocardial infarction or ST-segment elevation myocardial infarction.

Fragmin (dalteparin) is an anticoagulant (blood thinner), a type of heparin indicated to prevent ischemic complications in unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin therapy. Fragmin is also used for the prevention of deep vein thrombosis in certain patients.

Lovenox may interact with fragmin, nonsteroidal anti-inflammatory drugs (NSAIDs), and other medicines to prevent blood clots.

Lovenox may also interact with dextran.

Fragmin may interact with dextran, abciximab, eptifibatide, ticagrelor, tirofiban, alteplase, reteplase, tenecteplase, urokinase, anagrelide, cilostazol, clopidogrel, dipyridamole, eltrombopag, oprelvekin, prasugrel, romiplostim, ticagrelor, ticlopidine, argatroban, bivalirudin, dabigatran, lepirudin, enoxaparin, fondaparinux, heparin, rivaroxaban, tinzaparin, warfarin, NSAIDs (nonsteroidal anti-inflammatory drugs) or salicylates such as aspirin and others. Tell your doctor all medications and supplements you use. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether dalteparin passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

The recommended dose of Lovenox for most patients is 5 mg taken orally twice daily.

The recommended dose of Lovenox is 2.5 mg twice daily in patients with at least two of the following characteristics:

• age ≥ 80 years
• body weight ≤ 60 kg
• serum creatinine ≥ 1.5 mg/dL

Fragmin is available in single-dose, prefilled syringes preassembled with a needle guard device, and multiple-dose vials. Fragmin is administered by subcutaneous injection.