Evenity vs. Fosamax

• Are Evenity and Fosamax the Same Thing?
• What Are Possible Side Effects of Evenity?
• What Are Possible Side Effects of Fosamax?
• What Is Evenity?
• What Is Fosamax?
• What Drugs Interact with Evenity?
• What Drugs Interact with Fosamax?
• How Should Evenity Be Taken?
• How Should Fosamax Be Taken?

Evenity (romosozumab-aqqg) and Fosamax (alendronate sodium) are used to treat osteoporosis.

Evenity is specifically used in postmenopausal women at high risk for fracture.

Fosamax is also used to prevent osteoporosis, and to treat Paget's disease.

Evenity and Fosamax belong to different drug classes. Evenity is a sclerostin inhibitor and Fosamax is a bisphosphonate that is a specific inhibitor of osteoclast-mediated bone resorption.

Side effects of Evenity and Fosamax that are similar include joint pain, headache, swelling of extremities, and weakness.

Side effects of Evenity that are different from Fosamax include muscle spasms, neck pain, insomnia, and numbness and tingling sensation.

Side effects of Fosamax that are different from Evenity include gas, constipation, heartburn, diarrhea, bloating, nausea, vomiting, stomach pain, joint swelling, dizziness, eye pain, and back pain.

Evenity may interact with other drugs.

Fosamax may interact with aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs).

Common side effects of Evenity include:

• joint pain,
• headache,
• muscle spasms,
• swelling of extremities,
• weakness,
• neck pain,
• insomnia,
• numbness and
• tingling sensation

Common side effects of Fosamax include:

• gas,
• constipation,
• heartburn,
• diarrhea,
• bloating,
• nausea,
• vomiting,
• stomach pain,
• joint pain or swelling,
• swelling in your hands or feet,
• dizziness,
• headache,
• eye pain,
• back pain, or
• weakness.

Serious side effects of Fosamax include:

• severe pain (joints, bone, muscle, jaw, back or heartburn),
• chest pain,
• difficulty swallowing,
• bloody stools,
• eye pain,
• skin blisters, and
• swelling of the face, tongue, or throat.

Evenity (romosozumab-aqqg) is a sclerostin inhibitor indicated for the treatment of osteoporosis in postmenopausal women at high risk for fracture, defined as a history of osteoporotic fracture, or multiple risk factors for fracture; or patients who have failed or are intolerant to other available osteoporosis therapy.

Fosamax (alendronate sodium) is a bisphosphonate that is a specific inhibitor of osteoclast-mediated bone resorption used to both treat and prevent osteoporosis, and to treat Paget's disease.

Evenity may interact with digoxin. Tell your doctor all medication

Evenity may interact with other drugs. Tell your doctor all medications and supplements you use. Evenity is not recommended for use in women of reproductive potential so it is not intended for use by women who are pregnant or breastfeeding.

Fosamax may interact with aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs).

A healthcare provider can administer 210 mg Evenity subcutaneously once every month for 12 doses in the abdomen, thigh, or upper arm. Two separate subcutaneous injections are needed to administer the total dose of 210 mg Evenity.

Fosamax is available in a tablet or oral liquid form. Each bottle of the oral solution contains 91.35 mg of alendronate monosodium salt trihydrate, which is the molar equivalent to 70 mg of the drug. The recommended initial dosage is one 70 mg molar equivalent tablet or oral liquid bottle once weekly or one 10 mg molar equivalent tablet per day. Fosamax must be taken at least one-half hour before the first food, beverage, or medication of the day with plain water only to avoid any reduction in gastrointestinal adsorption.