Imitrex vs. Treximet

• Are Imitrex and Treximet the Same Thing?
• What Are Possible Side Effects of Imitrex?
• What Are Possible Side Effects of Treximet?
• What is Imitrex?
• What is Treximet?
• What Drugs Interact with Imitrex?
• What Drugs Interact with Treximet?
• How Should Imitrex Be Taken?
• How Should Treximet Be Taken?

Imitrex (sumatriptan) and Treximet (sumatriptan and naproxen sodium) are used to treat migraine headaches.

Imitrex is a selective serotonin receptor agonist (also called a triptan) and Treximet is a combination of a triptan and a nonsteroidal anti-inflammatory drug (NSAID).

Common side effects of Imitrex include:

• mild headache (not a migraine),
• pain or chest tightness,
• pressure or heavy feeling in any part of your body,
• weakness,
• feeling hot or cold,
• dizziness,
• spinning sensation,
• drowsiness,
• nausea,
• vomiting,
• drooling,
• unusual taste in your mouth after using nasal spray,
• burning/numbness/pain/irritation in your nose or throat after using nasal spray, or
• flushing (warmth, redness, or tingling under the skin).

Common side effects of Treximet include:

• dizziness
• drowsiness
• flushing (warmth, heat, or tingly feeling)
• redness in your face
• feelings of prickling/heat
• tiredness
• nausea
• heartburn
• constipation
• upset stomach
• dry mouth
• tight muscles
• weakness
• mild pressure or heavy feeling in any part of your body

Imitrex (sumatriptan) is a selective serotonin receptor agonist used in oral, intranasal or injectable dosage form to treat migraine headaches. Imitrex is available as a generic drug.

Treximet (sumatriptan and naproxen sodium) is a combination of a headache medicine and a nonsteroidal anti-inflammatory drug (NSAID) used to treat migraine headaches. Treximet will only treat a headache that has already begun.

Imitrex may interact with sibutramine (Meridia); monoamine oxidase inhibitors (MAOIs) isocarboxazid (Marplan); selective serotonin reuptake inhibitors, fluoxetine (Prozac) and sertraline (Zoloft), serotonin; norepinephrine reuptake inhibitors, venlafaxine (Effexor)) and duloxetine (Cymbalta); and ergot-containing medications, dihydroergotamine (Migranal) and ergotamine (Methergine).

Treximet may interact with blood thinners, lithium, methotrexate, probenecid, diuretics (water pills), steroids, aspirin, other NSAIDs (nonsteroidal anti-inflammatory drugs), ACE inhibitors, beta-blockers, or antidepressants.

The maximum single recommended adult dose of Imitrex Injection for the acute treatment of migraine or cluster headache is 6 mg injected subcutaneously. For the treatment of migraine, if side effects are dose limiting, lower doses (1 mg to 5 mg) of Imitrex may be used.

Treximet is a tablet with a fixed dose combination of 85 mg sumatriptan and 500 mg naproxen sodium. The usual dose is one tablet.