Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Spots, Brushfield's
Medically reviewed by Min Clinic Staff | Updated: January 2026
Spots, Brushfield's: Speckled iris. Little white spots that slightly elevated on the surface of the iris and are arranged in a ring concentric with the pupil. These spots occur in normal children but are far more frequent in Down's syndrome (trisomy 21). They were described in 1924 by Thomas Brushfield and are due to aggregation of a normal iris element (connective tissue).