Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Pycnodysostosis
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
Pycnodysostosis: An inherited disorder of bone that causes short stature and abnormally dense brittle bones. Pycnodysostosis can be due to a defect in the enzyme cathepsin K. Sometimes spelled pyknodysostosis. The French artist Toulouse-Lautrec is thought to have had this disease. No specific treatment is available.