Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Proband
Medically reviewed by Min Clinic Staff | Updated: January 2026
Proband: The family member through whom a family's medical history comes to attention. For example, a proband might be a baby with Down syndrome. The proband may also be called the index case, propositus (if male), or proposita (if female).