Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Polygenic disease
Medically reviewed by Min Clinic Staff | Updated: January 2026
Polygenic disease: A genetic disorder that is caused by the combined action of more than one gene. Examples of polygenic conditions include hypertension, coronary heart disease, and diabetes. Because such disorders depend on the simultaneous presence of several genes, they are not inherited as simply as are single-gene diseases.