Definition of MADH4

MADH4: A tumor suppressor gene (also known as SMAD4/DPC4) located on chromosome 18 in band 18q21 1. About 15% to 20% of cases of juvenile polyposis are due to germline mutations in MADH4. About 90% of pancreatic carcinomas show homozgous loss (loss of both copies) of MADH4.