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Definition of Iris, speckled
Medically reviewed by Min Clinic Staff | Updated: January 2026
Iris, speckled: Due to little white (or lightly colored) spots that are slightly elevated on the surface of the iris. These spots, arranged in a ring concentric with the pupil, occur normally, but more frequently, in Down syndrome (trisomy 21). They were described in 1924 by Thomas Brushfield, are called Brushfield's spots, and are due to aggregation of a normal iris element (connective tissue).