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Definition of Institutional Review Board

Medically reviewed by Min Clinic Staff | Updated: January 2026

Institutional Review Board: IRB. A group of scientists, doctors, clergy, and consumers at each health care facility that participates in a clinical trial. IRBs are designed to protect study participants. They review and must approve the action plan for every clinical trial. They check to see that the trial is well designed, does not involve undue risks, and includes safeguards for patients.