Adalat
- Generic Name: nifedipine
- Brand Name: Adalat CC
Adalat CC(Nifedipine) side effects drug center
Adalat Side Effects Center
What Is Adalat?
Adalat (nifedipine) is a calcium channel blocker drug that relaxes (widens) blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload and is used to lower high blood pressure (hypertension) and to treat chest pain (angina).
What Are Side Effects of Adalat?
Side effects of Adalat include:
- headache,
- dizziness,
- fatigue,
- tiredness,
- drowsiness,
- flushing (warmth, redness, or tingly feeling under your skin),
- sleep problems (insomnia),
- vivid or abnormal dreams,
- nausea,
- stomach pain,
- diarrhea,
- constipation,
- rash or itching,
- joint pain,
- leg/muscle cramps,
- increased urination, or
- sexual problems.
Tell your doctor if you have unlikely but serious side effects of Adalat including:
- swelling of the ankles or feet,
- shortness of breath, or
- unusual weakness or tiredness.
Dosage for Adalat?
Adalat is taken orally in tablet form. The usual maintenance dose of Adalat is 30 mg to 60 mg once daily.
What Drugs, Substances, or Supplements Interact with Adalat?
Adalat may interact with azole antifungals, antibiotics, grapefruit, nefazodone, fluoxetine, antiviral drugs, rifampin, rifabutin, phenobarbital, phenytoin, carbamazepine, St. John's Wort, antiarrhythmics, other calcium channel blockers, ACE inhibitors, angiotensin-II blockers, beta blockers, central alpha1 blockers, digoxin, anticoagulants, diuretics, and other drugs. Tell your doctor all medications and supplements you use.
Adalat During Pregnancy and Breastfeeding
It is not known whether nifedipine will be harmful to an unborn baby. Do not take nifedipine without first talking to your doctor if you are pregnant or could become pregnant during treatment. Nifedipine is known to be excreted in human breast milk, and nursing mothers are advised not to breastfeed their babies when taking the drug.
Additional Information
Our Adalat Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Adalat Consumer Information
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Call your doctor at once if you have:
- worsening chest pain;
- pounding heartbeats or fluttering in your chest;
- a light-headed feeling, like you might pass out;
- swelling in your hands or lower legs; or
- upper stomach pain, jaundice (yellowing of the skin or eyes).
You may have more severe or more frequent episodes of angina when you first start taking nifedipine or whenever your dose is changed.
Common side effects may include:
- swelling;
- flushing (warmth, redness, or tingly feeling);
- headache, dizziness;
- nausea, heartburn; or
- feeling weak or tired.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Adalat (Nifedipine)
Adalat Professional Information
SIDE EFFECTS
Adverse Experiences
The incidence of adverse events during treatment with Adalat CC in doses up to 90 mg daily were derived from multi-center placebo-controlled clinical trials in 370 hypertensive patients. Atenolol 50 mg once daily was used concomitantly in 187 of the 370 patients on Adalat CC and in 64 of the 126 patients on placebo. All adverse events reported during Adalat CC therapy were tabulated independently of their causal relationship to medication.
The most common adverse event reported with Adalat CC was peripheral edema. This was dose related and the frequency was 18% on Adalat CC 30 mg daily, 22% on Adalat CC 60 mg daily and 29% on Adalat CC 90 mg daily versus 10% on placebo.
Other common adverse events reported in the above placebo-controlled trials include:
| Adverse Event | ADALAT CC (%) (n=370) |
PLACEBO(%) (n=126) |
| Headache | 19 | 13 |
| Flushing/heat sensation | 4 | 0 |
| Dizziness | 4 | 2 |
| Fatigue/asthenia | 4 | 4 |
| Nausea | 2 | 1 |
| Constipation | 1 | 0 |
Where the frequency of adverse events with Adalat CC and placebo is similar, causal relationship cannot be established.
The following adverse events were reported with an incidence of 3% or less in daily doses up to 90 mg:
Body as a Whole/Systemic: chest pain, leg pain
Central Nervous System: paresthesia, vertigo
Dermatologic: rash
Gastrointestinal: constipation
Musculoskeletal: leg cramps
Respiratory: epistaxis, rhinitis
Urogenital: impotence, urinary frequency
Other adverse events reported with an incidence of less than 1.0% were:
Body as a Whole/Systemic: allergic reaction, asthenia, cellulitis, substernal chest pain, chills, facial edema, lab test abnormal, malaise, neck pain, pelvic pain, pain, photosensitivity reaction Cardiovas cular: atrial fibrillation, bradycardia, cardiac arrest, extrasystole, hypotension, migraine, palpitations, phlebitis, postural hypotension, tachycardia, cutaneous angiectases
Central Nervous System: anxiety, confusion, decreased libido, depression, hypertonia, hypesthesia, insomnia, somnolence
Dermatologic: angioedema, petechial rash, pruritus, sweating
Gastrointestinal: abdominal pain, diarrhea, dry mouth, dysphagia, dyspepsia, eructation, esophagitis, flatulence, gastrointestinal disorder, gastrointestinal hemorrhage, GGT increased, gum disorder, gum hemorrhage, vomiting
Hematologic: eosinophilia, lymphadenopathy
Metabolic: gout, weight loss
Musculoskeletal: arthralgia, arthritis, joint disorder, myalgia, myasthenia
Respiratory: dyspnea, increased cough, rales, pharyngitis, stridor
Special Senses : abnormal vision, amblyopia, conjunctivitis, diplopia, eye disorder, eye hemorrhage, tinnitus
Urogenital/Reproductive: dysuria, kidney calculus, nocturia, breast engorgement, polyuria, urogenital disorder, erectile dysfunction (ED)
The following adverse events have been reported rarely in patients given nifedipine in coat core or other formulations: allergenic hepatitis, alopecia, anaphylactic reaction, anemia, arthritis with ANA (+), depression, erythromelalgia, exfoliative dermatitis, fever, gingival hyperplasia, gynecomastia, hyperglycemia, jaundice, leukopenia, mood changes, muscle cramps, nervousness, paranoid syndrome, purpura, shakiness, sleep disturbances, Stevens-Johnson syndrome, syncope, taste perversion, thrombocytopenia, toxic epidermal necrolysis, transient blindness at the peak of plasma level, tremor and urticaria.
Read the entire FDA prescribing information for Adalat (Nifedipine)
&Copy; Adalat Patient Information is supplied by Cerner Multum, Inc. and Adalat Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.