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Diisopropyl Phosphorofluoridate: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Diisopropyl Phosphorofluoridate - General Information

An irreversible cholinesterase inhibitor with actions similar to those of echothiophate. It is a powerful miotic used mainly in the treatment of glaucoma. Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically. (From Martindale, The Extra Pharmacopoeia, 29th ed, p1330)

 

Pharmacology of Diisopropyl Phosphorofluoridate

Diisopropyl Phosphorofluoridate is used as ocular drops in the treatment of chronic glaucoma. Diisopropyl Phosphorofluoridate is an organophosphorus compound that acts as an irreversible cholinesterase inhibitor. As such, it displays parasympathomimetic effects. Diisopropyl Phosphorofluoridate is used in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. They may also be used in the diagnosis of certain eye conditions, such as accommodative esotropia. Diisopropyl Phosphorofluoridate damages the acetylcholinesterase enzyme and is therefore irreversible, however, pralidoxime can displace organophosphates such as isoflurophate from acetylcholinesterase, but only if administered before isoflurophate damages (alkylates) the enzyme.

 

Additional information about Diisopropyl Phosphorofluoridate

Diisopropyl Phosphorofluoridate Indication

For use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.

Mechanism Of Action
The mechanism of isoflurophate's action involves the irreversible inhibition of cholinesterase.
Generic Name
Isoflurophate
Synonyms
DFP; Diflupyl; Diflurophate; Diisopropoxyphosphoryl Fluoride
Drug Category
Antiglaucomic Agents; Ophthalmics; Cholinesterase Inhibitors; Miotics; Protease Inhibitors
Drug Type
Small Molecule; Approved
Other Brand Names containing Isoflurophate
Diisopropyl Fluoridophosphate; Diisopropyl Fluorophosphate; Diisopropyl Fluorophosphonate; Diisopropyl Phosphofluoridate; Diisopropyl Phosphorofluoridate; Diisopropylfluorfosfat; Disiopropyl Fluorophosphonate; Dyflos; Floropryl; Fluorodiisopropyl Phosphate; Fluoropryl; Fluostigmine; Fluropryl; Humorsol; Isofluorophate; Isofluorphate; Isoflurophosphate; Isopropyl Fluophosphate; Isopropyl Phosphorofluoridate; Neoglaucit; O,O-Diisopropyl Fluorophosphate; PF-3;
Toxicity (Overdose)
Signs of overdose include increased sweating, loss of bladder control, muscle weakness, nausea, vomiting, diarrhea, or stomach cramps or pain, shortness of breath, tightness in chest, or wheezing, slow or irregular heartbeat, unusual tiredness or weakness, watering of mouth.
Chemical IUPAC Name
2-(fluoro-propan-2-yloxyphosphoryl)oxypropane
Chemical Formula
C6H14FO3P
Organisms Affected
Humans and other mammals