Deuslon-A: Full Drug Profile
Deuslon-A - General Information
A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Deuslon-A is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol.
Pharmacology of Deuslon-A
Deuslon-A (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.
Additional information about Deuslon-A
Deuslon-A Indication: Used as a test to determine the general health of an unborn fetus. Mechanism Of Action: Deuslon-A levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta. If levels of "unconjugated estriol" are abnormally low in a pregnant woman, this may indicate a problem with the development of the child. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Estriol Synonyms: Oestriol; (16alpha,17beta)-Oestra-1,3,5(10)-triene-3,16,17-triol; (16alpha,17beta)-estra-1,3,5(10)-triene-3,16,17-triol; 1,3,5(10)-Estratriene-3,16alpha,17beta-triol; 1,3,5-Estratriene-3beta,16alpha,17beta-triol; 1,3,5-Oestratriene-3beta,16alpha,17beta-triol; 16-alpha,17-beta-Estriol; 16-alpha,17-beta-Oestriol; 16-alpha-Hydroxyestradiol; 16-alpha-Hydroxyoestradiol; 16alpha,17beta-Estriol; 16alpha,17beta-Oestriol; 16alpha-Hydroxy-17beta-estradiol; 16alpha-Hydroxyoestradiol; 16alpha-hydroxyestradiol; 3,16-alpha,17-beta-Estriol; 3,16-alpha,17-beta-Oestriol; 3,16-alpha,17-beta-Trihydroxy-delta-1,3,5-estratriene; 3,16-alpha,17-beta-Trihydroxy-delta-1,3,5-oestratriene; 3,16-alpha,17-beta-Trihydroxyestra-1,3,5(10)-triene; 3,16-alpha,17-beta-Trihydroxyoestra-1,3,5(10)-triene; 3,16alpha,17beta-Estriol; 3,16alpha,17beta-Trihydroxy-1,3,5(10)-estratriene; 3,16alpha,17beta-Trihydroxy-delta-1,3,5-oestratriene; 3,16alpha,17beta-trihydroxy-Delta(1,3,5)-estratriene; ESL; Estra-1,3,5(10)-trien-3,16alpha,17beta-triol; Estra-1,3,5(10)-triene-3,16,17-triol; Estratriol; Estriolo [italian]; Oestra-1,3,5(10)-triene-3,16alpha,17beta-triol; Oestriolum; Ovestrion; Tridestrin; 1,3,5(10)-Estratriene-3,16,17-Triol Drug Category: Estrogens Drug Type: Small Molecule; Approved Other Brand Names containing Estriol: Deuslon-A; Estriel; Absorption: Not Available Toxicity (Overdose): ORAL (LD50): Acute: >2000 mg/kg [Rat]. Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Deuslon-A: Not Available Chemical IUPAC Name: (8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol Chemical Formula: C18H24O3 Estriol on Wikipedia: https://en.wikipedia.org/wiki/Estriol Organisms Affected: Humans and other mammals
