Medical Information Only: This medication is not sold on this site. The information provided is for reference purposes only. Please consult your local physician or pharmacist for treatment.

Daranide: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Daranide - General Information

A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. [PubChem]

 

Pharmacology of Daranide

Daranide is an oral carbonic anhydrase inhibitor indicated for adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure. Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow).

 

Daranide for patients

 

Daranide Interactions

Caution is advised in patients receiving concomitant high-dose aspirin and carbonic anhydrase inhibitors, as anorexia, tachypnea, lethargy and coma have been rarely reported due to a possible drug interaction.

 

Daranide Contraindications

DARANIDE is contraindicated in hepatic insufficiency, renal failure, adrenocortical insufficiency, hyperchloremic acidosis, or in conditions in which serum levels of sodium or potassium are depressed. DARANIDE should not be used in patients with severe pulmonary obstruction who are unable to increase their alveolar ventilation since their acidosis may be increased.

DARANIDE is contraindicated in patients who are hypersensitive to this product.

 

Additional information about Daranide

Daranide Indication

For adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure

Mechanism Of Action
Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow), although the mechanism by which they do this is not fully understood. Evidence suggests that HCO3- ions are produced in the ciliary body by hydration of carbon dioxide under the influence of carbonic anhydrase and diffuse into the posterior chamber which contains more Na+ and HCO3- ions than does plasma and consequently is hypertonic. Water is then attracted to the posterior chamber by osmosis, resulting in a drop in pressure.
Generic Name
Dichlorphenamide
Synonyms
Diclofenamida [Inn-Spanish]; Diclofenamide; Diclofenamidum [Inn-Latin]; Dichlorphenamid; Dichlorophenamide; Dichlofenamide
Drug Category
Antiglaucomic Agents; Ophthalmics
Drug Type
Small Molecule; Approved
Other Brand Names containing Dichlorphenamide
Antidrasi; Daranide; Dasanide; Glaucol; Oratrol;
Protein Binding
55%
Dosage Forms of Daranide
Tablet Oral
Chemical IUPAC Name
4,5-dichlorobenzene-1,3-disulfonamide
Chemical Formula
C6H6Cl2N2O4S2
Organisms Affected
Humans and other mammals