Cumid: Full Drug Profile

Cumid - General Information

An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases. [PubChem]

Pharmacology of Cumid

Cumid is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X). It is also used in biochemical experiments as an inhibitor of reductases.

Additional information about Cumid

Cumid Indication

For decreasing blood clotting

Mechanism Of Action

Cumid inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.

Generic Name

Dicumarol

Synonyms

Dicoumarol; Bis-Hydroxycoumarin; BHC; Bishydroxycoumarin; Dicoumarin

Drug Category

Uncoupling Agents; Anticoagulants; Enzyme Inhibitors

Drug Type

Small Molecule; Approved

Other Brand Names containing Dicumarol

Acadyl; Acavyl; Antitrombosin; Baracoumin; Cuma; Cumid; Dicoumal; Dicuman; Dicumaol R; Dicumarine; Dicumol; Dikumarol; Dufalone; Kumoran; Melitoxin; Temparin; Trombosan;

Toxicity (Overdose)

LD₅₀=233 mg/kg (orally in mice); LD₅₀=250 mg/kg (orally in rats)

Dosage Forms of Cumid

Tablet Oral

Chemical IUPAC Name

2-hydroxy-3-[(2-hydroxy-4-oxochromen-3-yl)methyl]chromen-4-one

Chemical Formula

C19H12O6

Dicumarol on Wikipedia

https://en.wikipedia.org/wiki/Dicumarol

Organisms Affected

Humans and other mammals