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Chloronase: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Chloronase - General Information

A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)

 

Pharmacology of Chloronase

Chloronase, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Chloronase is twice as potent as the related second-generation agent glipizide.

 

Chloronase for patients

 

Chloronase Interactions

The hypoglycemic action of sulfonylurea may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents. When such drugs are administered to a patient receiving DIABINESE, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving DIABINESE, the patient should be observed closely for loss of control.

Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving DIABINESE, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving DIABINESE, the patient should be observed closely for hypoglycemia.

Since animal studies suggest that the action of barbiturates may be prolonged by therapy with chlorpropamide, barbiturates should be employed with caution. In some patients, a disulfiram-like reaction may be produced by the ingestion of alcohol.

A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical, or vaginal preparations of miconazole is not known.

 

Chloronase Contraindications

DIABINESE is contraindicated in patients with:

1. Known hypersensitivity to the drug.

2. Diabetic ketoacidosis, with or without coma. This condition should be treated with insulin.

 

Additional information about Chloronase

Chloronase Indication: For managing hyperglycemia in Non-insulin-dependent diabetes mellitus (NIDDM). Mechanism Of Action: Sulfonylureas such as Chloronase likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin. Drug Interactions: Acebutolol The beta-blocker decreases the symptoms of hypoglycemia Aspirin The salicylate increases the effect of sulfonylurea Atenolol The beta-blocker decreases the symptoms of hypoglycemia Betaxolol The beta-blocker decreases the symptoms of hypoglycemia Bevantolol The beta-blocker decreases the symptoms of hypoglycemia Bismuth The salicylate increases the effect of sulfonylurea Bisoprolol The beta-blocker decreases the symptoms of hypoglycemia Carteolol The beta-blocker decreases the symptoms of hypoglycemia Carvedilol The beta-blocker decreases the symptoms of hypoglycemia Chloramphenicol The agent increases the effect of sulfonylurea Clofibrate The agent increases the effect of sulfonylurea Diazoxide Diazoxyde/sulfonylurea: antagonism of action Dicumarol The agent increase the effect of sulfonylurea Esmolol The beta-blocker decreases the symptoms of hypoglycemia Glucosamine Possible hyperglycemia Isocarboxazid The MAO inhibitor increases the effect of hypoglycemic agent Labetalol The beta-blocker decreases the symptoms of hypoglycemia Metoprolol The beta-blocker decreases the symptoms of hypoglycemia Nadolol The beta-blocker decreases the symptoms of hypoglycemia Penbutolol The beta-blocker decreases the symptoms of hypoglycemia Phenelzine The MAO inhibitor increases the effect of hypoglycemic agent Phenylbutazone Phenylbutazone increases the effect of the hypoglycemic agent Pindolol The beta-blocker decreases the symptoms of hypoglycemia Practolol The beta-blocker decreases the symptoms of hypoglycemia Propranolol The beta-blocker decreases the symptoms of hypoglycemia Repaglinide Similar mode of action-questionable association Rifampin Rifampin decreases the effect of sulfonylurea Salsalate The salicylate increases the effect of sulfonylurea Sotalol The beta-blocker decreases the symptoms of hypoglycemia Sulfacytine Sulfonamide/sulfonylurea: possible hypoglycemia Sulfadiazine Sulfonamide/sulfonylurea: possible hypoglycemia Sulfadoxine Sulfonamide/sulfonylurea: possible hypoglycemia Sulfamethizole Sulfonamide/sulfonylurea: possible hypoglycemia Sulfamethoxazole Sulfonamide/sulfonylurea: possible hypoglycemia Sulfapyridine Sulfonamide/sulfonylurea: possible hypoglycemia Sulfasalazine Sulfonamide/sulfonylurea: possible hypoglycemia Sulfisoxazole Sulfonamide/sulfonylurea: possible hypoglycemia Timolol The beta-blocker decreases the symptoms of hypoglycemia Tranylcypromine The MAO inhibitor increases the effect of hypoglycemic agent Trisalicylate-choline The salicylate increases the effect of sulfonylurea Oxprenolol The beta-blocker decreases the symptoms of hypoglycemia Sulfamerazine Sulfonamide/sulfonylurea: possible hypoglycemia Sulfamethazine Sulfonamide/sulfonylurea: possible hypoglycemia Food Interactions: Take without regard to meals. Avoid alcohol. Food reduces the rate of absorption. Generic Name: Chlorpropamide Synonyms: Not Available Drug Category: Hypoglycemic Agents; Sulfonylureas Drug Type: Small Molecule; Approved Other Brand Names containing Chlorpropamide: Adiaben; Apo-Chlorpropamide; Asucrol; Catanil; Chlorodiabina; Chloronase; Chloropropamide; Chlorpropamid; Chlorpropamide Bp/ Usp; Clorpropamide; Diabaril; Diabechlor; Diabenal; Diabenese; Diabeneza; Diabet-Pages; Diabetoral; Diabinese; Diamel Ex; Dynalase; Glisema; Glucamide; Insulase; Meldian; Melitase; Mellinese; Millinese; Novo-Propamide; Oradian; Stabinol; Absorption: Not Available Toxicity (Overdose): IPN-RAT LD50 580 mg/kg Protein Binding: Not Available Biotransformation: Not Available Half Life: 36 hours Dosage Forms of Chloronase: Tablet Oral Chemical IUPAC Name: 1-(4-chlorophenyl)sulfonyl-3-propylurea Chemical Formula: C10H13ClN2O3S Chlorpropamide on Wikipedia: https://en.wikipedia.org/wiki/Chlorpropamide Organisms Affected: Humans and other mammals