Medical Information Only: This medication is not sold on this site. The information provided is for reference purposes only. Please consult your local physician or pharmacist for treatment.

Cemastin: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Cemastin - General Information

A cephalosporin antibiotic.

 

Pharmacology of Cemastin

Cemastin (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally.

 

Additional information about Cemastin

Cemastin Indication

Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract.

Mechanism Of Action
The bactericidal activity of cefalotin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Generic Name
Cefalotin
Synonyms
Cefalotina [INN-Spanish]; Cefalotine [INN-French]; Cefalotinum [INN-Latin]; Cephalothin Sodium; Cephalothinum; Cephalothin; Cephalotin; CLS; Cefalothin
Drug Category
Anti-Bacterial Agents
Drug Type
Small Molecule; Approved
Other Brand Names containing Cefalotin
Averon-1; Cemastin; Coaxin; Keflin; Seffin;
Toxicity (Overdose)
Rat intravenous LD50 is 4000 mg/kg.
Protein Binding
65-80%
Biotransformation
Metabolized to a less active desacetyl metabolite, although 50-75% of the drug is eliminated unchanged in the urine.
Half Life
30 minutes
Dosage Forms of Cemastin
Powder, for solution Intravenous
Chemical IUPAC Name
(6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Chemical Formula
C16H16N2O6S2
Organisms Affected
Enteric bacteria and other eubacteria