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Benefix (Genetics Institute): Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Benefix (Genetics Institute) - General Information

Human Factor IX protein, produced by recombinant DNA technology for use in therapy of factor IX deficiency, known as hemophilia B or Christmas disease. Benefix (Genetics Institute) (Recombinant) is a glycoprotein with an approximate molecular mass of 55,000 Da consisting of 415 amino acids in a single chain. It has a primary amino acid sequence that is identical to the Ala 148 allelic form of plasma-derived factor IX.

 

Pharmacology of Benefix (Genetics Institute)

Binds vitamin K and factor VIIIa. Cleaves the Arg-Ile bond in factor X to form active factor Xa. Plays a key role in blood coagulation and clotting. Injections of factor IX are used to treat hemophilia B, which is sometimes called Christmas disease. AlphaNine is injected to increase plasma levels of Factor IX and can temporarily correct this coagulation defect.

 

Benefix (Genetics Institute) for patients

 

Benefix (Genetics Institute) Interactions

 

Benefix (Genetics Institute) Contraindications

Because BeneFIX�, Coagulation Factor IX (Recombinant), is produced in a Chinese hamster ovary cell line, it may be contraindicated in patients with a known history of hypersensitivity to hamster protein..

 

Additional information about Benefix (Genetics Institute)

Benefix (Genetics Institute) Indication: For treatment of hemophilia (Christmas disease). Mechanism Of Action: Cleaves the Arg-Ile bond in Factor X to form active factor Xa leading to coagulation and clotting. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Coagulation Factor IX Synonyms: Christmas factor; Coagulation factor IX precursor; PTC; Plasma thromboplastin component Drug Category: Coagulants; Thrombotic Agents Drug Type: Biotech; Approved Other Brand Names containing Coagulation Factor IX: Benefix (Genetics Institute); Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: 19.4 ± 5.4 hours (range from 11 to 36 hours) Dosage Forms of Benefix (Genetics Institute): Injection, powder, lyophilized, for solution Intravenous Chemical IUPAC Name: Human factor IX protein Chemical Formula: C2041H3136N558O641S25 Coagulation Factor IX on Wikipedia: https://en.wikipedia.org/wiki/Factor_IX Organisms Affected: Humans and other mammals