Amnoid: Full Drug Profile
Amnoid - General Information
Amnoid is a novel synthetic retinoid for acute promyelocytic leukaemia (APL). Amnoid is currently approved in Japan for treatment of recurrent APL, and is undergoing clinical trials in the United States.
Pharmacology of Amnoid
Amnoid is a new synthetic retinoid drug recently approved for relapsed or refractory acute promyelocytic leukemia (APL) in Japan. It is a specific agonist for retinoic acid receptor alpha/beta. Compared to all-trans retinoic acid (ATRA), a natural retinoid indicated for a first-line treatment of APL, tamibarotene is chemically more stable and several times more potent as an inducer of differentiation in promyelocytic leukemia cells. In contrast to ATRA, whose plasma concentration declines considerably during daily administration, tamibarotene sustains plasma level probably due to a lower affinity for cellular retinoic acid binding protein. Furthermore, adverse side effects were milder than those of ATRA in clinical trials.
Additional information about Amnoid
- Amnoid Indication
Investigated for use/treatment in leukemia (unspecified).
- Mechanism Of Action
- Amnoid is a specific agonist for retinoic acid receptor alpha/beta.
- Generic Name
- Tamibarotene
- Synonyms
- Am 80; retinobenzoic acid
- Drug Category
- Anticancer Agents
- Drug Type
- Small Molecule; Approved; Investigational
- Other Brand Names containing Tamibarotene
- Amnoid; Tamibaro;
- Protein Binding
- Over 99%, predominantly to serum albumin.
- Chemical IUPAC Name
- 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
- Chemical Formula
- C22H25NO3
- Organisms Affected
- Humans and other mammals
