Ambrocef: Full Drug Profile

Ambrocef - General Information

Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms.

Pharmacology of Ambrocef

Ambrocef is a first-generation cephalosporin that has a wide spectrum of activity against gram-positive and gram-negative organisms. Ambrocef is more resistant to beta-lactamases than are the penicillins and so is effective against staphylococci, with the exception of methicillin-resistant staphylococci.

Additional information about Ambrocef

Ambrocef Indication

For treatment of infections caused by susceptible bacteria.

Mechanism Of Action

The bactericidal activity of cephapirin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).

Generic Name

Cephapirin

Synonyms

Cefapirin; Cefapirina [INN-Spanish]; Cefapirine [INN-French]; Cefapirinum [INN-Latin]; Cefaprin sodium; Cefaprin; Cephapirin Sodium; Cephapirine

Drug Category

Anti-Bacterial Agents

Drug Type

Small Molecule; Approved

Other Brand Names containing Cephapirin

Ambrocef; Cefa; Cefatrex; Cefatrexyl; Cefadyl;

Toxicity (Overdose)

Rats exposed via the oral route to cephapirin displayed low acute toxicity (LD₅₀ = 14000 mg/kg). The most common adverse reactions are hypersensitivity reactions and alterations to liver function. Evidence of white blood cell disorders and anaemia were noted in some subjects.

Biotransformation

Major metabolite detected is desacetylcephapirin.

Chemical IUPAC Name

(6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-pyridin-4-ylsulfanylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Chemical Formula

C17H17N3O6S2

Organisms Affected

Enteric bacteria and other eubacteria