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Aldurazyme (Biomarin Pharmaceuticals): Full Drug Profile

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

Aldurazyme (Biomarin Pharmaceuticals) - General Information

Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Aldurazyme (Biomarin Pharmaceuticals) is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase. It contains 6 N-linked oligosaccharide modification sites.

 

Pharmacology of Aldurazyme (Biomarin Pharmaceuticals)

Aldurazyme (Biomarin Pharmaceuticals) is used to treat mucopolysaccharide storage disorders (specifically mucopolysaccharidosis 1 or Hurlers syndrome) caused by deficiencies of alpha-L-iduronidase. Reduced or absent a-L-iduronidase activity results in the accumulation of the GAG substrates, dermatan sulfate and heparan sulfate, throughout the body and leads to widespread cellular, tissue, and organ dysfunction.

 

Aldurazyme (Biomarin Pharmaceuticals) for patients

 

Aldurazyme (Biomarin Pharmaceuticals) Interactions

No formal drug interaction studies have been conducted.

 

Aldurazyme (Biomarin Pharmaceuticals) Contraindications

There are no known contraindications to the use of ALDURAZYME.

 

Additional information about Aldurazyme (Biomarin Pharmaceuticals)

Aldurazyme (Biomarin Pharmaceuticals) Indication: For the treatment of mucopolysaccharidosis Mechanism Of Action: Aldurazyme (Biomarin Pharmaceuticals) catalyses the hydrolysis of terminal alpha-L-iduronic acid residues of dermatan sulfate and heparin sulfate. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Laronidase Synonyms: Alpha-L-iduronidase precursor Drug Category: Enzyme Replacement Agents Drug Type: Biotech; Approved Other Brand Names containing Laronidase: Aldurazyme (Biomarin Pharmaceuticals); Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: 1.5-3.6 hrs Dosage Forms of Aldurazyme (Biomarin Pharmaceuticals): Solution Intravenous Chemical IUPAC Name: Human alpha-L-iduronidase Chemical Formula: C3160H4848N898O881S12 Laronidase on Wikipedia: https://en.wikipedia.org/wiki/Laronidase Organisms Affected: Humans and other mammals