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Adagen (Enzon Inc.): Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Adagen (Enzon Inc.) - General Information

Bovine adenosine deaminase derived from bovine intestine that has been extensively pegylated for extended serum half life

 

Pharmacology of Adagen (Enzon Inc.)

Used to replace deficient or inactive adenosine deaminase which leads to severe combined immunodeficiency disease (SCID). The enzyme is responsible for converting adenosine to inosine. In the absence of adenosine deaminase, the purine substrates adenosine, 2'-deoxyadenosine and their metabolites are actually toxic to lymphocytes thereby leading to diminished immune function.

 

Adagen (Enzon Inc.) for patients

 

Adagen (Enzon Inc.) Interactions

There are no known drug interactions with ADAGEN� (pegademase bovine) Injection. However, Vidarabine is a substrate for ADA and 2'-deoxycoformycin is a potent inhibitor of ADA. Thus, the activities of these drugs and ADAGEN� (pegademase bovine) Injection could be substantially altered if they are used in combination with one another.

 

Adagen (Enzon Inc.) Contraindications

There is no evidence to support the safety and efficacy of ADAGEN� (pegademase bovine) Injection as preparatory or support therapy for bone marrow transplantation. Since ADAGEN� (pegademase bovine) Injection is administered by intramuscular injection, it should be used with caution in patients with thrombocytopenia and should not be used if thrombocytopenia is severe.

 

Additional information about Adagen (Enzon Inc.)

Adagen (Enzon Inc.) Indication

For treatment of adenosine deaminase deficiency

Mechanism Of Action
Pegademase converts adenosine (toxic) to inosine (less toxic) by deamination. It also converts 2'-deoxyadenosine to 2'-deoxyinosine via deamination.
Generic Name
Pegademase bovine
Synonyms
Adenosine aminohydrolase; Adenosine deaminase
Drug Category
Enzyme Replacement Agents
Drug Type
Biotech; Approved
Other Brand Names containing Pegademase bovine
Adagen (Enzon Inc.);
Dosage Forms of Adagen (Enzon Inc.)
Injection, solution Intramuscular
Chemical IUPAC Name
bovine adenosine deaminase (PEGylated)
Chemical Formula
C1821H2834N484O552S14
Organisms Affected
Humans and other mammals