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Physostigmine: Detailed Datasheet

Medically reviewed by Min Clinic Staff | Updated: January 2026
  • Generic Name: physostigmine salicylate (injection)
  • Brand Name: Physostigmine Salicylate

side effects drug center physostigmine salicylate (physostigmine salicylate (injection)) drug - patient side effects and images

 

PROFESSIONAL

CONSUMER

SIDE EFFECTS

Physostigmine Patient Information Including Side Effects

Brand Names: Antilirium

Generic Name: physostigmine

What is physostigmine (Antilirium)?

Physostigmine affects chemicals in the body that control the signals sent from the nervous system to the muscles to activate muscle movement.

Physostigmine is used to reverse the effects of certain drugs or substances that interfere with this nerve-muscle communication. Such substances include atropine, scopolamine, belladonna, antihistamines, some antidepressants, and other anticholinergic (AN tye KOE lin ER jik) drugs.

Physostigmine may also be used for purposes not listed in this medication guide.

What are the possible side effects of physostigmine (Antilirium)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

  • increased urination or bowel movements;
  • stomach cramps;
  • severe or worsening nausea or vomiting;
  • increased sweating;
  • blurred vision; or
  • excessive saliva in your mouth.

Common side effects may include:

  • nausea, vomiting;
  • increased salivation; or
  • slow heartbeats.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about physostigmine (Antilirium)?

In an emergency situation it may not be possible to tell your caregivers about your health conditions. Make sure any doctor caring for you afterward knows you have received this medicine.

Physostigmine Patient Information including How Should I Take

What should I discuss with my healthcare provider before receiving physostigmine (Antilirium)?

You should not be treated with physostigmine if you are allergic to it, or if you have: