Omeclamox-Pak

Omeclamox-Pak (omeprazole delayed-release capsules 20 mg, clarithromycin tablets 500 mg, and amoxicillin capsules 500 mg) is a combination of a proton pump inhibitor (PPI), a macrolide antimicrobial, and a penicillin antibiotic, indicated for the treatment of patients with Helicobacter pylori infection and duodenal ulcer disease (active or up to one-year history) to eradicate H. pylori. Common side effects of Omeclamox-Pak include:

• diarrhea
• changes in taste, and
• headache

The adult dosing regimen of Omeclamox-Pak is omeprazole 20 mg plus clarithromycin 500 mg plus amoxicillin 1000 mg, each given twice daily for 10 days in the morning and evening before eating a meal. Omeclamox-Pak may interact with antiarrythmics, oral anticoagulants, atazanavir, nelfinavir, saquinavir, cilostazol, tacrolimus, theophylline, carbamazepine, sildenafil, HMG-CoA reductase inhibitors (statins), diazepam, warfarin, phenytoin, cyclosporine, disulfiram, benzodiazepines, probenecid, ketoconazole, iron salts, ampicillin esters, digoxin, and mycophenolate mofetil. Tell your doctor all medications and supplements you use. Omeclamox-Pak is not recommended for use during pregnancy. The omeprazole and clarithromycin in Omeclamox-Pak may harm a fetus. The omeprazole and amoxicillin in Omeclamox-Pak pass into breast milk. It is unknown if clarithromycin passes into breast milk. Breastfeeding while taking Omeclamox-Pak is not recommended.

Our Omeclamox-Pak (omeprazole delayed-release capsules 20 mg, clarithromycin tablets 500 mg, and amoxicillin capsules 500 mg) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

• severe stomach pain, diarrhea that is watery or bloody;
• fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
• liver problems--upper stomach pain, itching, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);
• kidney problems--urinating more or less than usual, blood in your urine, swelling, rapid weight gain; or
• new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.

Serious side effects may be more likely in older adults.

Taking amoxicillin, clarithromycin, and omeprazole long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.

Common side effects may include:

• diarrhea;
• headache; or
• unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Omeclamox-Pak (Omeprazole Delayed-release Capsules)