Zonegran vs. Lyrica
- Are Zonegran and Lyrica the Same Thing?
- What Are Possible Side Effects of Zonegran?
- What Are Possible Side Effects of Lyrica?
- What Is Zonegran?
- What Is Lyrica?
- What Drugs Interact with Zonegran?
- What Drugs Interact with Lyrica?
- How Should Zonegran Be Taken?
- How Should Lyrica Be Taken?
Are Lyrica and Zonegran the Same Thing?
Zonegran (zonisamide) and Lyrica (pregabalin) are anticonvulsants used to treat partial seizures in adults with epilepsy.
Lyrica is also used to treat neuropathic (nerve) pain associated with diabetic peripheral neuropathy or postherpetic neuralgia, and for treating fibromyalgia.
Side effects of Zonegran and Lyrica that are similar include drowsiness, dizziness, loss of balance or coordination, and blurred vision.
Side effects of Zonegran that are different from Lyrica include headache, tired feeling, loss of appetite, weight loss, sore throat, cough, trouble sleeping, diarrhea, and double vision.
Side effects of Lyrica that are different from Zonegran include dry mouth, constipation, fluid retention (edema), breast swelling, tremors, weight gain, and problems with memory or concentration.
Both Zonegran and Lyrica may interact with alcohol, other medicines that make you sleepy (such as cold or allergy medicines, sedatives, narcotics, sleeping pills, muscle relaxers, and medicines for depression or anxiety), and other seizure medications.
Zonegran may also interact with topiramate and cold or allergy medicines that contain antihistamines.
Lyrica may also interact with oral diabetes medicines and ACE inhibitors.
What Are Possible Side Effects of Zonegran?
Common side effects of Zonegran include:
- drowsiness,
- dizziness,
- headache,
- tired feeling,
- loss of appetite,
- weight loss,
- loss of balance or coordination,
- sore throat,
- cough,
- trouble sleeping,
- diarrhea,
- blurred vision, or
- double vision.
Tell the doctor immediately if you notice serious side effects of Zonegran including increased or worsening seizures, lightheadedness, shortness of breath, rapid heart rate, trouble concentrating, fever, chills, sores in your mouth and throat, severe pain in your lower back, blood in your urine, feeling very thirsty or hot, being unable to urinate, or severe skin reaction.
What Are Possible Side Effects of Lyrica?
Side effects of Lyrica nclude<:/p>
- drowsiness,
- dry mouth,
- dizziness,
- blurred vision,
- constipation,
- weight gain,
- trouble urinating,
- headache,
- increased hunger, and
- changes in taste.
What Is Zonegran?
Zonegran (zonisamide) is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor indicated as adjunctive therapy in the treatment of partial seizures in adults with epilepsy.
What Is Lyrica?
Lyrica (pregabalin) is an anti-epileptic drug (anticonvulsant) used for neuropathic (nerve) pain associated with diabetic peripheral neuropathy or postherpetic neuralgia, and for treating partial onset seizures in adults, and fibromyalgia.

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See ImagesWhat Drugs Interact With Zonegran?
Zonegran may interact with other medicines that can make you sleepy (cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for depression or anxiety) or other seizure medications. Lyrica may also interact with lithium, hydrochlorothiazide, metformin, atropine, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, bronchodilators, bladder or urinary medications, or glaucoma medications.
What Drugs Interact With Lyrica?
Lyrica may interact with alcohol, other medicines that can make you sleepy (sold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for anxiety), or rosiglitazone.
How Should Zonegran Be Taken?
The dose of Zonegran is 25 mg or 100 mg capsules administered orally once or twice daily.
How Should Lyrica Be Taken?
The recommended dose of Lyrica is 75-600 mg daily. Alcohol and drugs that cause sedation may increase the sedative effects of Lyrica. There are no adequate studies of Lyrica in pregnant women. If you become pregnant, your name may be listed on a pregnancy registry to track the outcome of the pregnancy and to evaluate any effects of Lyrica on the baby. It is unknown if Lyrica passes into breast milk or if it could harm a nursing baby. Breastfeeding while using Lyrica is not recommended.