Vumerity vs. Gilenya

• Are Vumerity and Gilenya the Same Thing?
• What Are Possible Side Effects of Vumerity?
• What Are Possible Side Effects of Gilenya?
• What Is Vumerity?
• What Is Gilenya?
• What Drugs Interact with Vumerity?
• What Drugs Interact with Gilenya?
• How Should Vumerity Be Taken?
• How Should Gilenya Be Taken?

Vumerity (diroximel fumarate) and Gilenya (fingolimod) are used to treat relapsing forms of multiple sclerosis (MS).

Vumerity and Gilenya belong to different drug classes. Vumerity is an immunomodulator and Gilenya is a sphingosine 1-phosphate receptor modulator.

Side effects of Vumerity and Gilenya that are similar include diarrhea.

Side effects of Vumerity that are different from Gilenya include flushing, abdominal pain, nausea, vomiting, itching, rash, albumin in the urine, redness, and indigestion/heartburn.

Side effects of Gilenya that are different from Vumerity include headache, tired feeling, influenza, stuffy nose, sinus pain, back pain, liver transaminase elevations, and cough.

Vumerity may interact with dimethyl fumarate.

Gilenya may also interact with beta-blockers, calcium channel blockers, citalopram, chlorpromazine, digoxin, erythromycin, haloperidol, ketoconazole, medications to control the immune system, medications for cancer, medicines to treat heart problems or high blood pressure, and methadone.

Common side effects of Vumerity include:

• flushing,
• abdominal pain,
• diarrhea,
• nausea,
• vomiting,
• itching,
• rash,
• albumin in the urine,
• redness, and
• indigestion/heartburn

Common side effects of Gilenya include:

• headache,
• tired feeling,
• influenza,
• stuffy nose,
• sinus pain,
• diarrhea,
• back pain,
• liver transaminase elevations, and
• cough.

Gilenya can affect your immune system's ability to fight an infection while you are taking the medication and for 2 months after your last dose. Tell your doctor right away if you develop signs of an infection such as:

• persistent cough or sore throat,
• difficulty breathing,
• fever,
• chills, or
• cold/flu symptoms.

Vumerity (diroximel fumarate) is an immunomodulator indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

Gilenya (fingolimod) is a sphingosine 1-phosphate receptor modulator used to treat patients with relapsing forms of multiple sclerosis (MS) to reduce the frequency of exacerbations and to delay physical disability.

Vumerity may interact with other medicines such as:

• dimethyl fumarate

Tell your doctor all medications and supplements you use.

Gilenya may interact with beta-blockers, calcium channel blockers, citalopram, chlorpromazine, digoxin, erythromycin, haloperidol, ketoconazole, medications to control the immune system, medications for cancer, heart problems, or high blood pressure, and methadone. Tell your doctor all medications and supplements you use. Gilenya may cause fetal harm. It takes approximately 2 months for Gilenya to be eliminated from the body. Women should avoid pregnancy during treatment with Gilenya and for 2 months after treatment. It is not known if Gilenya passes into breast milk. Women and their doctors should decide whether to take Gilenya or breastfeed. Women should not do both.

The starting dose of Vumerity is 231 mg twice a day, orally, for 7 days. The maintenance dose of Vumerity after 7 days is 462 mg (administered as two 231 mg capsules) twice a day, orally.

The recommended dose for Gilenya is 0.5 mg orally once daily, with or without food.