Trikafta vs. Symdeko: Comparison
Are Trikafta and Symdeko the Same Thing?
Trikafta (elexacaftor, tezacaftor and ivacaftor tablets; ivacaftor tablets) and Symdeko (tezacaftor/ivacaftor tablets and ivacaftor tablets) are combination drugs used to treat cystic fibrosis (CF) in patients aged 12 years and older who have at least one F508del mutation in the CFTR gene.
Side effects of Trikafta and Symdeko that are similar include headache and runny or stuffy nose.
Side effects of Trikafta that are different from Symdeko include upper respiratory tract infection, abdominal pain, diarrhea, rash, sneezing or post-nasal drip, influenza, sinusitis, increased alanine aminotransferase, increased blood creatine phosphokinase, increased aspartate aminotransferase, and increased blood bilirubin.
Side effects of Symdeko that are different from Trikafta include nausea and dizziness.
Both Trikafta and Symdeko may interact with rifampin, rifabutin, seizure medications, St. John's wort, azole antifungals, macrolide antibiotics, digoxin, cyclosporine, everolimus, sirolimus, and tacrolimus.
Trikafta may also interact with glimepiride and glipizide, statins, glyburide, nateglinide, and repaglinide.
Symdeko may also interact with grapefruit and Seville oranges.
What Are Possible Side Effects of Trikafta?
Common side effects of Trikafta include:
- headache,
- upper respiratory tract infection,
- abdominal pain,
- diarrhea,
- rash,
- increased alanine aminotransferase,
- runny or stuffy nose,
- increased blood creatine phosphokinase,
- increased aspartate aminotransferase,
- sneezing or post-nasal drip,
- influenza,
- sinusitis, and
- increased blood bilirubin
What Are Possible Side Effects of Symdeko?
Common side effects of Symdeko include:
- headache,
- nausea,
- stuffy nose, and
- dizziness
What Is Trikafta?
Trikafta (elexacaftor, tezacaftor and ivacaftor tablets; ivacaftor tablets) is a combination of ivacaftor, a CFTR potentiator, tezacaftor, and elexacaftor used to treat cystic fibrosis (CF) in patients aged 12 years and older who have at least one F508del mutation in the CFTR gene. If the patient’s genotype is unknown, an FDA-cleared CF mutation test should be used to confirm the presence of at least one F508del mutation.
What Is Symdeko?
Symdeko (tezacaftor/ivacaftor tablets and ivacaftor tablets) is a combination drug indicated for the treatment of patients with cystic fibrosis (CF) aged 12 years and older who are homozygous for the F508delmutation or who have at least one mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that is responsive to tezacaftor/ivacaftor based on in vitrodata and/or clinical evidence.
What Drugs Interact With Trikafta?
Trikafta may interact with other medicines such as:
- rifampin,
- rifabutin,
- seizure medications,
- St. John’s wort,
- azole antifungals,
- macrolide antibiotics,
- glimepiride and glipizide,
- digoxin,
- cyclosporine,
- everolimus,
- sirolimus,
- tacrolimus,
- statins,
- glyburide,
- nateglinide, and
- repaglinide
Tell your doctor all medications and supplements you use.
What Drugs Interact With Symdeko?
Symdeko should be taken with fat-containing food. Symdeko may interact with:
- ketoconazole,
- fluconazole,
- grapefruit,
- Seville oranges,
- rifampin,
- rifabutin,
- phenobarbital,
- carbamazepine,
- phenytoin,
- St. John's wort,
- itraconazole,
- posaconazole,
- voriconazole,
- telithromycin,
- clarithromycin,
- erythromycin,
- digoxin,
- cyclosporine,
- everolimus,
- sirolimus, and
- tacrolimus
Tell your doctor all medications and supplements you use.
How Should Trikafta be Taken?
The morning dose of Trikafta for adults and pediatric patients aged 12 years and older is two elexacaftor 100 mg, tezacaftor 50 mg and ivacaftor 75 mg tablets. The evening dose of Trikafta for adults and pediatric patients aged 12 years and older is one ivacaftor 150 mg tablet. The morning and evening doses of Trikafta should be taken approximately 12 hours apart with fat-containing food.
How Should Symdeko be Taken?
The adults and pediatric (ages 12 years and older) dose of Symdeko is one tablet (containing tezacaftor 100 mg/ivacaftor 150 mg) in the morning and one tablet (containing ivacaftor 150 mg) in the evening, approximately 12 hours apart.