Dupixent vs. Xolair

Dupixent (dupilumab) injection and Xolair (omalizumab) are monoclonal antibodies used to treat moderate to severe asthma.

Dupixent is also used to treat adult patients with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. Dupixent can be used with or without topical corticosteroids.

Side effects of Dupixent and Xolair that are similar include injection site reactions (itching, redness, stinging, pain, bruising, warmth, burning, or swelling).

Side effects of Dupixent that are different from Xolair include pink eye (conjunctivitis), swollen or puffy eyelids, oral herpes, inflammation of the cornea (keratitis), eye itching, other herpes simplex virus infection, and dry eye.

Side effects of Xolair that are different from Dupixent include headache, tired feeling, joint or muscle pain, dizziness, ear pain, hair loss, sore throat, cold symptoms, itching or skin rash, and leg or arm pain.

Dupixent may interact with "live" vaccines, warfarin, and cyclosporine.

Xolair may interact with allergy shots.

Common side effects of Dupixent include:

• injection site reactions,
• pink eye (conjunctivitis),
• swollen or puffy eyelids,
• oral herpes,
• inflammation of the cornea (keratitis),
• eye itching,
• other herpes simplex virus infection, and
• dry eye.

Common side effects of Xolair include:

• headache,
• tired feeling,
• joint or muscle pain,
• dizziness,
• ear pain,
• hair loss,
• sore throat,
• cold symptoms,
• itching or skin rash,
• injection site reactions (itching, redness, stinging, pain, bruising, warmth, burning, or swelling), or
• leg or arm pain.

Tell your doctor if you have serious side effects of Xolair including unusual lumps/growths/moles.

Dupixent (dupilumab) injection is aninterleukin-4 receptor alpha-antagonist indicated for the treatment of adult patients with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. Dupixent can be used with or without topical corticosteroids.

Xolair (omalizumab) is an antibody that helps decrease allergic responses in the body used to treat moderate to severe asthma that is caused by allergies in adults and children who are at least 12 years old. Xolair is usually given after other asthma medications have been tried without successful treatment of symptoms.

Dupixent may interact with:

• "live" vaccines
• warfarin, or
• cyclosporine

Before using Xolair, tell your doctor if you are receiving allergy shots. There may be other drugs that can interact with Xolair. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Xolair should be used only when prescribed during pregnancy. It is not known whether this drug passes into breast milk. Consult your doctor before breastfeeding.

The recommended dose of Dupixent is an initial dose of 600 mg (two 300 mg injections in different injection sites), followed by 300 mg given every other week.

Xolair in a dose of 150 to 375 mg is administered by injection every 2 or 4 weeks.