Combipatch vs. Climara Pro

• Are Combipatch and Climara Pro the Same Thing?
• What Are Possible Side Effects of Combipatch?
• What Are Possible Side Effects of Climara Pro?
• What is Combipatch?
• What is Climara Pro?
• What Drugs Interact with Combipatch?
• What Drugs Interact with Climara Pro?
• How Should Combipatch Be Taken?
• How Should Climara Pro Be Taken?

CombiPatch (estradiol, norethindrone acetate) and Climara Pro (estradiol/levonorgestrel) are transdermal patches that are combinations of female hormones used to treat the symptoms of menopause such as feelings of warmth in the face, neck and chest, or sudden intense spells of heat and sweating ("hot flashes" or "hot flushes").

CombiPatch is also used to treat vulvar and vaginal changes (itching, burning, dryness in or around the vagina, difficulty or burning with urination) caused by menopause, and to replace estrogen in conditions such as hypogonadism, removal of the ovaries, or primary ovarian failure that result in a lack of estrogen.

Climara is also used to prevent osteoporosis (bone loss) in menopausal women.

Common side effects of Combipatch include:

• skin redness/irritation/rash at the application site,
• abdominal pain,
• nausea,
• vomiting,
• bloating,
• breast tenderness or enlargement,
• weakness,
• swelling of the hands or feet,
• spotty darkening of the skin (particularly on the face),
• difficulty wearing contact lenses,
• vaginal irritation or discomfort,
• changes in menstrual cycle,
• painful menstruation,
• breakthrough bleeding,
• headache, or
• weight changes.

Common side effects of Climara Pro include:

• patch application site reactions (skin redness, irritation, or skin rash),
• abdominal pain,
• nausea,
• vomiting,
• bloating,
• breast tenderness or swelling,
• headache,
• weight changes,
• swelling of the hands or feet,
• darkened spots on the skin of your face,
• contact lens discomfort,
• vaginal irritation or discomfort,
• depression, or
• changes in your menstrual periods.

CombiPatch (estradiol, norethindrone acetate transdermal system) is a combination of female hormones used to treat the symptoms of menopause such as feelings of warmth in the face, neck and chest, or sudden intense spells of heat and sweating ("hot flashes" or "hot flushes"); to treat vulvar and vaginal changes (itching, burning, dryness in or around the vagina, difficulty or burning with urination) caused by menopause; and to replace estrogen in conditions such as hypogonadism, removal of the ovaries, or primary ovarian failure that result in a lack of estrogen.

Climara Pro (estradiol/levonorgestrel) transdermal patch is a combination of female hormones used to treat menopause symptoms such as hot flashes, and to prevent osteoporosis (bone loss) in menopausal women. Climara Pro will not prevent dementia, heart attack, heart disease, or stroke.

CombiPatch may interact with anticoagulants (blood thinners).

CombiPatch and Climara may interact with anticoagulants (blood thinners).

Two CombiPatch transdermal delivery systems are available: 0.05 mg estradiol with 0.14 mg NETA per day (9 sq cm) and 0.05 mg estradiol with 0.25 mg NETA per day (16 sq cm). The lowest effective dose should be used.

A Climara Pro patch with a dose of 0.045 mg estradiol / 0.015 mg levonorgestrel (22 sq cm) is worn continuously on the lower abdomen. A new system should be applied weekly during a 28-day cycle.