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Definition of Hybridoma
Medically reviewed by Min Clinic Staff | Updated: January 2026
Hybridoma: A hybrid cell used as the basis for the production of antibodies in large amounts for diagnostic or therapeutic use. Hybridomas are produced by injecting a specific antigen into a mouse, collecting an antibody-producing cell from the mouse's spleen, and fusing it with a tumor cell called a myeloma cell. The hybridoma cells multiply indefinitely in the laboratory and can be used to produce a specific antibody indefinitely.