Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Exfoliate
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
Exfoliate: 1) To peel off scaly skin spontaneously. The skin exfoliates from the palms and soles in Kawasaki's disease and Reiter's syndrome. 2) To deliberately wear away the top layer of skin, as may be done gently by a facial technologist who applies a topical skin treatment for cosmetic purposes, or more aggressively by a dermatologist treating acne.