Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Dihydroorotate dehydrogenase
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
Dihydroorotate dehydrogenase: An enzyme necessary to pyrimidine synthesis and therefore essential to the production of DNA and RNA. The drug leflunomide (Arava), an immunomodulatory agent, acts by specifically inhibiting dihydroorotate dehydrogenase.
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