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Definition of Aberration
Medically reviewed by Min Clinic Staff | Updated: January 2026
Aberration: (1) A deviation or irregularity. For example, a chromosome aberration is a deviation from the normal chromosome number or the normal chromosome structure. In this sense, aberration is also synonymous with deflection, departure, divergence, diversion, turning. (2) A mental aberration is a significant deviation from normal mental activity. In this sense, aberration is synonymous with mental derangement, mental illness, psychopathy.