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Definition of ADCC (antibody-dependent cell-mediated cytotoxicity)

Medically reviewed by Min Clinic Staff | Updated: January 2026

ADCC (antibody-dependent cell-mediated cytotoxicity): An immune response in which antibodies, by coating target cells, makes them vulnerable to attack by immune cells. Antibody-dependent cell-mediated cytotoxicity is commonly (and blissfully) abbreviated ADCC.