Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Pisa syndrome
Medically reviewed by Min Clinic Staff | Updated: January 2026
Pisa syndrome: A condition in which there is sustained involuntary flexion of the body and head to one side and slight rotation of the trunk so the person appears to lean like the Leaning Tower of Pisa.
The Pisa syndrome is an adverse effect (a side-effect) of some medications. It occurs sometimes following the long-term use of narcoleptics (drugs used to treat schizophrenia) or cholinesterase inhibitors (a class of drugs used to treat Alzheimer disease).